Runx proteins (also known as Runt-domain transcription factors) have been studied for a
long time as key regulators of cellular differentiation. RUNX2 has been described as …

Background RUNX1 is a transcription factor and a master regulator for the specification of
the hematopoietic lineage during embryogenesis and postnatal megakaryopoiesis …

Recent studies have revealed that chemokine-like factor-like MARVEL transmembrane
domain-containing family member 6 (CMTM6) promotes tumor progression and modulates …

Myelodysplastic syndromes (MDSs) are a heterogeneous group of hematologic
malignancies with a propensity to progress to acute myeloid leukemia. Causal mutations in …

RUNX proteins are highly conserved in metazoans and perform critical functions during
development. Dysregulation of RUNX proteins through various molecular mechanisms …

Studies of induced granulocytic differentiation help to reveal molecular mechanisms of cell
maturation. The nuclear proteome represents a rich source of regulatory molecules …

MicroRNAs (miRNAs) are small non‑coding RNAs that serve key roles in cell proliferation,
migration, invasion and apoptosis by regulating gene expression. In malignant tumors …

As a transcription factor in the RUNT domain core-binding factor family, RUNX1 is crucial in
multiple stages of hematopoiesis, and its mutation can cause familial platelet disorder with a …

Background: Breast cancer is the most common malignant tumor in women. RUNX family
has been involved in the regulation of different carcinogenic processes and signaling …

Genomic integrity is continuously threatened by thousands of endogenous and exogenous
damaging factors. To preserve genome stability, cells developed comprehensive DNA …