Lactate cross-talk in host–pathogen interactions

A Llibre, FS Grudzinska, MK O'Shea, D Duffy… - Biochemical …, 2021 - portlandpress.com
Lactate is the main product generated at the end of anaerobic glycolysis or during the
Warburg effect and its role as an active signalling molecule is increasingly recognised …

Lactate's impact on immune cells in sepsis: Unraveling the complex interplay

T Zhang, L Chen, G Kueth, E Shao, X Wang… - Frontiers in …, 2024 - frontiersin.org
Lactate significantly impacts immune cell function in sepsis and septic shock, transcending
its traditional view as just a metabolic byproduct. This review summarizes the role of lactate …

Interferon signaling drives epithelial metabolic reprogramming to promote secondary bacterial infection

GP Carreno-Florez, BR Kocak, MR Hendricks… - PLoS …, 2023 - journals.plos.org
Clinical studies report that viral infections promote acute or chronic bacterial infections at
multiple host sites. These viral-bacterial co-infections are widely linked to more severe …

Host-based diagnostics for acute respiratory infections

MH Ross, BL Zick, EL Tsalik - Clinical therapeutics, 2019 - Elsevier
Purpose The inappropriate use of antimicrobials, especially in acute respiratory infections
(ARIs), is largely driven by difficulty distinguishing bacterial, viral, and noninfectious …

Neutrophil count in sputum is associated with increased sputum glucose and sputum L-lactate in cystic fibrosis

BU Nielsen, M Kolpen, PØ Jensen, T Katzenstein… - Plos one, 2020 - journals.plos.org
Background Markers of lung inflammation measured directly in expectorated sputum have
the potential of improving the timing of antibiotic treatment in cystic fibrosis (CF). L-Lactate …

“The Standard Procedure” for Investigation of Oral Neutrophils in Oral Diseases

PØ Jensen, PD Rikvold, KR Larsen… - … Journal of Dentistry, 2023 - Wiley Online Library
Aim. There is need of an objective “standard procedure” that is reliable and clinically
applicable for estimating oral neutrophil content in relation to oral diseases. Methods. Forty …

Endotracheal lactate reflects lower respiratory tract infections and inflammation in intubated patients

M Kolpen, C Dalby Sørensen, D Faurholt‐Jepsen… - APMIS, 2022 - Wiley Online Library
The aim of this study was to assess L‐lactate and D‐lactate in endotracheal aspirate from
intubated patients hospitalized at the intensive care unit and explore their use as diagnostic …

Antiviral response drives epithelial metabolic reprogramming to promote secondary bacterial infection

GP Carreno-Florez - 2023 - search.proquest.com
Increasing evidence shows that viral infections predispose the host to the acquisition of
acute or chronic bacterial infections. Viral-bacterial co-infections are often linked to more …

Improved cytometric analysis of untouched lung leukocytes by enzymatic liquefaction of sputum samples

G Santopolo, A Clemente, E Rojo-Molinero… - Biological procedures …, 2022 - Springer
Background Phenotyping sputum-resident leukocytes and evaluating their functional status
are essential analyses for exploring the cellular basis of pathological processes in the lungs …