Since human embryonic stem cells were first differentiated to beating cardiomyocytes a
decade ago, interest in their potential applications has increased exponentially. This has …

The partitioning of intracellular space beyond membrane-bound organelles can be achieved
with collections of proteins that are multivalent or contain low-complexity, intrinsically …

Eukaryotic cells contain assemblies of RNAs and proteins termed RNA granules. Many
proteins within these bodies contain KH or RRM RNA-binding domains as well as low …

Objectives: The purpose of this study was to test the ability of insulin-like growth factor (IGF)-
1/hepatocyte growth factor (HGF) to activate resident endogenous porcine cardiac …

The generation of human ventricular cardiomyocytes from human embryonic stem cells
and/or induced pluripotent stem cells could fulfill the demand for therapeutic applications …

1022 Circulation August 27, 2013 dehydrogenase activity. 14 Increases in cardiac
aldosterone have been reported in experimental models of myocardial infarction, 15 …

expanded from cardiac biopsies by different protocols. 9, 10 Very recently, the first patients
were treated with either cardiosphere-derived cardiac stem cells (CArdiosphere-Derived …

Cardiac muscle creation during embryogenesis requires extracellular instructive signals that
are regulated precisely in time and space, intersecting with intracellular genetic programs …

The unexpected discovery that somatic cells can be reprogrammed to a pluripotent state
yielding induced pluripotent stem cells has made it possible to produce cardiovascular cells …

We probed an epigenetic regulatory path from small molecule to neuronal gene activation.
Isoxazole small molecules triggered robust neuronal differentiation in adult neural stem …