Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Superoxide ion (O2•–) is of great significance as a radical species implicated in diverse
chemical and biological systems. However, the chemistry knowledge of O2•–is rather …

Nitric oxide (NO) is one of the most important molecules released by endothelial cells, and
its antiatherogenic properties support cardiovascular homeostasis. Diminished NO …

Free radicals contain one or more unpaired electrons in their valence shell, thus making
them unstable, short-lived, and highly reactive species. Excessive generation of these free …

Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …

Peroxynitrite is the product of the diffusion-controlled reaction of nitric oxide and superoxide
radicals. Peroxynitrite, a reactive short-lived peroxide with ap K a of 6.8, is a good oxidant …

There are many pieces of evidence suggesting the mediating role of reactive oxygen
species (ROS) in cell life, stress and death, and it is known that ROS at different …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Accumulating evidence suggests that oxidant stress alters many functions of the
endothelium, including modulation of vasomotor tone. Inactivation of nitric oxide (NO·) by …

Objectives In view of the critical role of intracellular Ca 2+-overload in the genesis of
myocyte dysfunction and the ability of reactive oxygen species (ROS) to induce the …