Chemical and biomolecular strategies for STING pathway activation in cancer immunotherapy

KM Garland, TL Sheehy, JT Wilson - Chemical reviews, 2022 - ACS Publications
The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …

Immunogenic cell death induction by ionizing radiation

M Zhu, M Yang, J Zhang, Y Yin, X Fan… - Frontiers in …, 2021 - frontiersin.org
Immunogenic cell death (ICD) is a form of regulated cell death (RCD) induced by various
stresses and produces antitumor immunity via damage-associated molecular patterns …

Ultrasound-augmented mitochondrial calcium ion overload by calcium nanomodulator to induce immunogenic cell death

P Zheng, B Ding, Z Jiang, W Xu, G Li, J Ding… - Nano letters, 2021 - ACS Publications
Immunogenic cell death (ICD), a manner of tumor cell death that can trigger antitumor
immune responses, has received extensive attention as a potential synergistic modality for …

Ce-net: Context encoder network for 2d medical image segmentation

Z Gu, J Cheng, H Fu, K Zhou, H Hao… - IEEE transactions on …, 2019 - ieeexplore.ieee.org
Medical image segmentation is an important step in medical image analysis. With the rapid
development of a convolutional neural network in image processing, deep learning has …

The STING1 network regulates autophagy and cell death

R Zhang, R Kang, D Tang - Signal transduction and targeted therapy, 2021 - nature.com
Cell death and immune response are at the core of life. In past decades, the endoplasmic
reticulum (ER) protein STING1 (also known as STING or TMEM173) was found to play a …

Bioactivable STING Nanoagonists to Synergize NIR‐II Mild Photothermal Therapy Primed Robust and Long‐Term Anticancer Immunity

W Ma, R Sun, L Tang, Z Li, L Lin, Z Mai… - Advanced …, 2023 - Wiley Online Library
Pharmacological activation of the stimulator of interferon genes (STING) pathway has
become a promising strategy for cancer immunotherapy. However, the insufficient tumorous …

Targeted scavenging of extracellular ROS relieves suppressive immunogenic cell death

H Deng, W Yang, Z Zhou, R Tian, L Lin, Y Ma… - Nature …, 2020 - nature.com
Immunogenic cell death (ICD) and tumour-infiltrating T lymphocytes are severely weakened
by elevated reactive oxygen species (ROS) in the tumour microenvironment. It is therefore of …

STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapy

L Wang-Bishop, BR Kimmel, VM Ngwa… - Science …, 2023 - science.org
The tumor-associated vasculature imposes major structural and biochemical barriers to the
infiltration of effector T cells and effective tumor control. Correlations between stimulator of …

Phosphorous dendron micelles as a nanomedicine platform for cooperative tumor chemoimmunotherapy via synergistic modulation of immune cells

M Zhan, J Qiu, Y Fan, L Chen, Y Guo… - Advanced …, 2023 - Wiley Online Library
Abstract Design of effective nanomedicines to modulate multiple immune cells to overcome
the immune‐suppressive tumor microenvironment is desirable to improve the overall poor …

Nanoparticle-enhanced chemo-immunotherapy to trigger robust antitumor immunity

J Liang, H Wang, W Ding, J Huang, X Zhou… - Science …, 2020 - science.org
Mounting evidence suggests that immunotherapies are a promising new class of anticancer
therapies. However, the immunosuppressive tumor microenvironment (TME), poor …