▪ Abstract DNA damage is a relatively common event in the life of a cell and may lead to
mutation, cancer, and cellular or organismic death. Damage to DNA induces several cellular …

As its name suggests, the ATM?'ataxia-telangiectasia, mutated'? gene is responsible for the
rare disorder ataxia-telangiectasia. Patients show various abnormalities, mainly in their …

To protect genome integrity and ensure survival, eukaryotic cells exposed to genotoxic
stress cease proliferating to provide time for DNA repair. Human cells responded to …

Complex assemblies of interacting proteins carry out most of the interesting jobs in a cell,
such as metabolism, DNA synthesis, movement and information processing. These …

New antifungal agents are urgently required to combat life-threatening infections caused by
opportunistic fungal pathogens like Candida albicans. The manipulation of endogenous …

Several newly identified tumor suppressor genes including ATM, NBS1, BRCA1 and BRCA2
are involved in DNA double-strand break repair (DSBR) and DNA damage-induced …

Tight regulation of cell cycle progression is essential for the maintenance of genomic
integrity. The orderly progression from one cell cycle phase to the other is mediated by timed …

Sensing DNA damage is crucial for the maintenance of genomic integrity and cell cycle
progression. The participation of chromatin in these events is becoming of increasing …

▪ Abstract The initiation of DNA replication in eukaryotic cells is tightly controlled to ensure
that the genome is faithfully duplicated once each cell cycle. Genetic and biochemical …

Saccharomyces cells with one unrepaired double-strand break (DSB) adapt after checkpoint-
mediated G2/M arrest. Adaptation is accompanied by loss of Rad53p checkpoint kinase …