Protein translation: biological processes and therapeutic strategies for human diseases

X Jia, X He, C Huang, J Li, Z Dong, K Liu - Signal Transduction and …, 2024 - nature.com
Protein translation is a tightly regulated cellular process that is essential for gene expression
and protein synthesis. The deregulation of this process is increasingly recognized as a …

Studying micro RNA function and dysfunction in Alzheimer's disease

WJ Lukiw, TV Andreeva, AP Grigorenko… - Frontiers in …, 2013 - frontiersin.org
Alzheimer's disease (AD) is a tragic, progressive, age-related neurological dysfunction,
representing one of the most prevalent neurodegenerative disorders in industrialized …

[HTML][HTML] Temozolomide resistance in glioblastoma occurs by miRNA-9-targeted PTCH1, independent of sonic hedgehog level

JL Munoz, V Rodriguez-Cruz, SH Ramkissoon… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Glioblastoma Multiforme (GBM), the most common and lethal adult primary tumor of the
brain, showed a link between Sonic Hedgehog (SHH) pathway in the resistance to …

MicroRNA-138-5p regulates pancreatic cancer cell growth through targeting FOXC1

C Yu, M Wang, Z Li, J Xiao, F Peng, X Guo, Y Deng… - Cellular oncology, 2015 - Springer
Purpose The prognosis of pancreatic cancer ranks among the worst of all cancer types,
which is primarily due to the fact that during the past decades little progress has been made …

Regulation network and expression profiles of Epstein-Barr virus-encoded microRNAs and their potential target host genes in nasopharyngeal carcinomas

ZY Zeng, HB Huang, LL Huang, MX Sun… - Science China Life …, 2014 - Springer
Epstein-Barr virus (EBV) is associated with nasopharyngeal carcinoma (NPC)
tumorigenesis. However, the mechanism (s) connecting EBV infection and NPC remain …

Long non-coding RNAs in cancer

ZJ Gong, SS Zhang, WL Zhang, HB Huang, Q Li… - Science China Life …, 2012 - Springer
Long non-coding RNAs (lncRNAs) are a group of RNA transcripts that exceed 200 nt in
length, yet lack significant open reading frames (ORFs)[1–4]. In contrast to small non-coding …

[HTML][HTML] Extracellular GAPDH promotes alzheimer disease progression by enhancing amyloid-β aggregation and cytotoxicity

VF Lazarev, M Tsolaki, ER Mikhaylova… - Aging and …, 2021 - ncbi.nlm.nih.gov
Neuronal cell death at late stages of Alzheimer's disease (AD) causes the release of
cytosolic proteins. One of the most abundant such proteins, glyceraldehyde-3-phosphate …

miRNA expression profiling in a human stem cell-based model as a tool for developmental neurotoxicity testing

G Pallocca, M Fabbri, MG Sacco, L Gribaldo… - Cell biology and …, 2013 - Springer
The main aim of this study was to evaluate whether microRNA (miRNA) profiling could be a
useful tool for in vitro developmental neurotoxicity (DNT) testing. Therefore, to identify the …

MicroRNA-21: expression in oligodendrocytes and correlation with low myelin mRNAs in depression and alcoholism

JJ Miguel-Hidalgo, KO Hall, H Bonner… - Progress in neuro …, 2017 - Elsevier
MiR-21 is a microRNA implicated in cancer, development, and cardiovascular diseases and
expressed in the central nervous system (CNS), especially after injury. However, the cellular …

[HTML][HTML] microRNA-137 modulates pancreatic cancer cells tumor growth, invasion and sensitivity to chemotherapy

J Xiao, F Peng, C Yu, M Wang, X Li, Z Li… - … Journal of Clinical …, 2014 - ncbi.nlm.nih.gov
Background: We intended to investigate the role of microRNA 137 (miR-137) in regulating
pancreatic cancer cells' growth in vitro and tumor development in vivo. Methods: QTR-PCR …