Design of artificial biomimetic channels with Na+ permeation rate and selectivity potentially outperforming the natural sodium channel

Z Zhu, Y Zhao, C Chang, S Yan, T Sun, S Gu, Y Li… - Nano Research, 2024 - Springer
Artificial ion channels that enable high-efficiency ion transport have important implications in
nanofluidics and biomedical applications such as drug delivery. Herein, we show a …

Effect of cholesterol on the membrane partitioning dynamics of hepatitis A virus-2B peptide

S Sikdar, M Banerjee, S Vemparala - Soft Matter, 2021 - pubs.rsc.org
Understanding viral peptide detection and partitioning and the subsequent host membrane
composition-based response is essential for gaining insights into the viral mechanism. Here …

[HTML][HTML] Microsecond simulation of human aquaporin 2 reveals structural determinants of water permeability and selectivity

S Padhi, UD Priyakumar - Biochimica et Biophysica Acta (BBA) …, 2017 - Elsevier
Abstract Human aquaporin 2 (AQP2) from the family of aquaporins assumes great
physiological importance, owing to its association with nephrogenic diabetes insipidus …

Assessing the physiological relevance of alternate architectures of the p7 protein of hepatitis C virus in different environments

N Holzmann, C Chipot, F Penin, F Dehez - Bioorganic & Medicinal …, 2016 - Elsevier
The viroporin p7 of the hepatitis C virus forms multimeric channels eligible for ion transport
across the endoplasmic reticulum membrane. Currently the subject of many studies and …

Urea–aromatic stacking and concerted urea transport: conserved mechanisms in urea transporters revealed by molecular dynamics

S Padhi, UD Priyakumar - Journal of Chemical Theory and …, 2016 - ACS Publications
Urea transporters are membrane proteins that selectively allow urea molecules to pass
through. It is not clear how these transporters allow rapid conduction of urea, a polar …

Ion Selectivity and Permeation Mechanism in a Cyclodextrin-Based Channel

P Musunuru, S Padhi… - The Journal of Physical …, 2021 - ACS Publications
Synthetic ion channels are a promising technology in the medical and materials sciences
because of their ability to conduct ions. Channels based on cyclodextrin, a cyclic oligomer of …

Resonance-driven ion transport and selectivity in prokaryotic ion channels

RL Westra - Physical Review E, 2019 - APS
Ion channels exhibit a remarkably high accuracy in selecting uniquely its associated type of
ion. The mechanisms behind ion selectivity are not well understood. Current explanations …

pH-mediated gating and formate transport mechanism in the Escherichia coli formate channel

S Padhi, LK Reddy, UD Priyakumar - Molecular Simulation, 2017 - Taylor & Francis
Formate channels play a crucial role in the metabolism of several different kinds of bacteria
by bringing about uptake and export of formate ions. The current study investigates the …

Cooperation of hydrophobic gating, knock-on effect, and ion binding determines ion selectivity in the p7 Channel

S Padhi, UD Priyakumar - The Journal of Physical Chemistry B, 2016 - ACS Publications
Ion channels selectively allow certain ions to pass through at much higher rates than others,
and thereby modulate ionic concentrations across cell membranes. The current molecular …

[PDF][PDF] Ion Selectivity and Permeation Mechanism in a Cyclodextrin-based Channel

M Pratyusha - 2021 - web2py.iiit.ac.in
Ion channels are proteins present across the lipid bilayer membrane possessing a pore that
selectively allows certain ions to pass through. They control various cellular processes and …