Abstract Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) belongs to glycoside hydrolase
family 18. It binds to chitin, heparin, and hyaluronic acid, and is regulated by extracellular …

Asthma is a common disease that affects 300 million people worldwide. Given the large
number of eosinophils in the airways of people with mild asthma, and verified by data from …

Background Susceptibility to asthma is influenced by genes and environment; implicated
genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful …

Understanding the consequences of regulatory variation in the human genome remains a
major challenge, with important implications for understanding gene regulation and …

Asthma and allergy are common conditions with complex etiologies involving both genetic
and environmental contributions. Recent genome‐wide association studies (GWAS) and …

Viral respiratory tract infections are common and usually selflimited illnesses. For patients at
risk of asthma, or with existing asthma, viral respiratory tract infections can have a profound …

Abstract Interleukin (IL)-4 and IL-13 were discovered approximately 30 years ago and were
immediately linked to allergy and atopic diseases. Since then, new roles for IL-4 and IL-13 …

The 18 glycosyl hydrolase family of chitinases is an ancient gene family that is widely
expressed from prokaryotes to eukaryotes. In mammals, despite the absence of endogenous …

Asthma is a common disorder that in 2009 afflicted 8.2% of adults and children, 24.6 million
persons, in the United States. In patients with moderate and severe persistent asthma, there …

The bacterial composition of the human fecal microbiome is influenced by many lifestyle
factors, notably diet. It is less clear, however, what role host genetics plays in dictating the …