Summary H3K9 methylation (H3K9me) marks transcriptionally silent genomic regions called
heterochromatin. HP1 proteins are required to establish and maintain heterochromatin. HP1 …

Faithful transfer of parental histones to newly replicated daughter DNA strands is critical for
inheritance of epigenetic states. Although replication proteins that facilitate parental histone …

The establishment of centromere-specific CENP-A chromatin is influenced by epigenetic
and genetic processes. Central domain sequences from fission yeast centromeres are …

Heterochromatin formation requires three distinct steps: nucleation, self-propagation
(spreading) along the chromosome, and faithful maintenance after each replication cycle …

Chromatin remodeling is essential to allow full development of alternative gene expression
programs in response to environmental changes. In fission yeast, oxidative stress triggers …

The epigenetic landscape of a cell frequently changes in response to fluctuations in nutrient
levels, but the mechanistic link is not well understood. In fission yeast, the JmjC domain …

Epe1 histone demethylase restricts H3K9-methylation-dependent heterochromatin,
preventing it from spreading over, and silencing, gene-containing regions in fission yeast …

CENP-A chromatin specifies mammalian centromere identity, and its chaperone HJURP
replenishes CENP-A when recruited by the Mis18 complex (Mis18C) via M18BP1/KNL2 to …

The role of model organisms such as yeasts in life science research is crucial. Although the
baker's yeast (Saccharomyces cerevisiae) is the most popular model among yeasts, the …

Heterochromatin spreading, the expansion of repressive chromatin structure from sequence-
specific nucleation sites, is critical for stable gene silencing. Spreading re-establishes gene …