Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality
worldwide. COPD heterogeneity has hampered progress in developing pharmacotherapies …

SUMMARY OF KEY POINTS International respiratory organizations now recommend using
lower limit of normal and standardized residuals to diagnose airflow obstruction and COPD …

The integration of quantitative trait loci (QTL) with disease genome-wide association studies
(GWAS) has proven successful at prioritizing candidate genes at disease-associated loci …

Accurate diagnosis of chronic obstructive pulmonary disease (COPD) and exacerbations by
metabolic biomarkers enables individualized treatment. Advanced metabolic detection …

Background It has been a long-held consensus that immune reactions primarily mediate the
pathology of chronic obstructive pulmonary disease (COPD), and that exosomes may …

Bronchopulmonary dysplasia (BPD) is the most common lung disease of extreme
prematurity, yet mechanisms that associate with or identify neonates with increased …

The onset of chronic obstructive pulmonary disease (COPD) is heterogeneous, and current
approaches to define distinct disease phenotypes are lacking. In addition to clinical …

Background/objectives Obesity, defined as excessive fat accumulation that represents a
health risk, is increasing in adults and children, reaching global epidemic proportions. Body …

COPD affects millions of people and is now ranked as the third leading cause of death
worldwide. This largely untreatable chronic airway disease results in irreversible destruction …

Background Genetic variants and gene expression predict risk of chronic obstructive
pulmonary disease (COPD), but their effect on COPD heterogeneity is unclear. We aimed to …