The central nucleus of the amygdala and the construction of defensive modes across the threat-imminence continuum
JM Moscarello, MA Penzo - Nature Neuroscience, 2022 - nature.com
In nature, animals display defensive behaviors that reflect the spatiotemporal distance of
threats. Laboratory-based paradigms that elicit specific defensive responses in rodents have …
threats. Laboratory-based paradigms that elicit specific defensive responses in rodents have …
The multifaceted role of the ventromedial prefrontal cortex in emotion, decision making, social cognition, and psychopathology
The ventromedial prefrontal cortex (vmPFC) has been implicated in a variety of social,
cognitive, and affective functions that are commonly disrupted in mental illness. In this …
cognitive, and affective functions that are commonly disrupted in mental illness. In this …
Identification of a prefrontal cortex-to-amygdala pathway for chronic stress-induced anxiety
WZ Liu, WH Zhang, ZH Zheng, JX Zou, XX Liu… - Nature …, 2020 - nature.com
Dysregulated prefrontal control over amygdala is engaged in the pathogenesis of psychiatric
diseases including depression and anxiety disorders. Here we show that, in a rodent anxiety …
diseases including depression and anxiety disorders. Here we show that, in a rodent anxiety …
Neuronal circuits for fear and anxiety
Decades of research has identified the brain areas that are involved in fear, fear extinction,
anxiety and related defensive behaviours. Newly developed genetic and viral tools …
anxiety and related defensive behaviours. Newly developed genetic and viral tools …
Behavioral and neurobiological mechanisms of pavlovian and instrumental extinction learning
This article reviews the behavioral neuroscience of extinction, the phenomenon in which a
behavior that has been acquired through Pavlovian or instrumental (operant) learning …
behavior that has been acquired through Pavlovian or instrumental (operant) learning …
Development of the emotional brain
In this article, we highlight the importance of dynamic reorganization of neural circuitry
during adolescence, as it relates to the development of emotion reactivity and regulation. We …
during adolescence, as it relates to the development of emotion reactivity and regulation. We …
Childhood adversity and neural development: Deprivation and threat as distinct dimensions of early experience
A growing body of research has examined the impact of childhood adversity on neural
structure and function. Advances in our understanding of the neurodevelopmental …
structure and function. Advances in our understanding of the neurodevelopmental …
The contextual brain: implications for fear conditioning, extinction and psychopathology
Contexts surround and imbue meaning to events; they are essential for recollecting the past,
interpreting the present and anticipating the future. Indeed, the brain's capacity to …
interpreting the present and anticipating the future. Indeed, the brain's capacity to …
[HTML][HTML] The brain on stress: vulnerability and plasticity of the prefrontal cortex over the life course
BS McEwen, JH Morrison - Neuron, 2013 - cell.com
The prefrontal cortex (PFC) is involved in working memory and self-regulatory and goal-
directed behaviors and displays remarkable structural and functional plasticity over the life …
directed behaviors and displays remarkable structural and functional plasticity over the life …
Early developmental emergence of human amygdala–prefrontal connectivity after maternal deprivation
DG Gee, LJ Gabard-Durnam… - Proceedings of the …, 2013 - National Acad Sciences
Under typical conditions, medial prefrontal cortex (mPFC) connections with the amygdala
are immature during childhood and become adult-like during adolescence. Rodent models …
are immature during childhood and become adult-like during adolescence. Rodent models …