Computational biology helps understand how polyploid giant cancer cells drive tumor success

MC Casotti, DD Meira, ASS Zetum, BC Araújo… - Genes, 2023 - mdpi.com
Precision and organization govern the cell cycle, ensuring normal proliferation. However,
some cells may undergo abnormal cell divisions (neosis) or variations of mitotic cycles …

Game Theory for Managing Evolving Systems: Challenges and Opportunities of Including Vector-Valued Strategies and Life-History Traits

M Kleshnina, S Streipert, JS Brown… - Dynamic Games and …, 2023 - Springer
Nature exhibits rapid evolution in response to human activities. When using natural
resources for their own profit, humans should account for such responses. Stackelberg …

Integrating eco‐evolutionary dynamics into matrix population models for structured populations: Discrete and continuous frameworks

A Bukkuri, JS Brown - Methods in Ecology and Evolution, 2023 - Wiley Online Library
State‐structured populations are ubiquitous in biology, from the age‐structure of animal
societies to the life cycles of parasitic species. Understanding how this structure contributes …

The contribution of evolvability to the eco‐evolutionary dynamics of competing species

A Bukkuri, KJ Pienta, SR Amend, RH Austin… - Ecology and …, 2023 - Wiley Online Library
Evolvability is the capacity of a population to generate heritable variation that can be acted
upon by natural selection. This ability influences the adaptations and fitness of individual …

A mathematical investigation of polyaneuploid cancer cell memory and cross-resistance in state-structured cancer populations

A Bukkuri, KJ Pienta, RH Austin, EU Hammarlund… - Scientific reports, 2023 - nature.com
The polyaneuploid cancer cell (PACC) state promotes cancer lethality by contributing to
survival in extreme conditions and metastasis. Recent experimental evidence suggests that …

A Schrödinger equation for evolutionary dynamics

VD Ao, DV Tran, KT Pham, DM Nguyen, HD Tran… - Quantum …, 2023 - mdpi.com
We establish an analogy between the Fokker–Planck equation describing evolutionary
landscape dynamics and the Schrödinger equation which characterizes quantum …

Modeling cancer's ecological and evolutionary dynamics

A Bukkuri, KJ Pienta, I Hockett, RH Austin… - Medical Oncology, 2023 - Springer
In this didactic paper, we present a theoretical modeling framework, called the G-function,
that integrates both the ecology and evolution of cancer to understand oncogenesis. The G …

Modeling stress-induced responses: plasticity in continuous state space and gradual clonal evolution

A Bukkuri - Theory in Biosciences, 2024 - Springer
Mathematical models of cancer and bacterial evolution have generally stemmed from a
gene-centric framework, assuming clonal evolution via acquisition of resistance-conferring …

Biomarkers or biotargets? Using competition to lure cancer cells into evolutionary traps

A Bukkuri, FR Adler - Evolution, Medicine, and Public Health, 2023 - academic.oup.com
Abstract Background and Objectives Cancer biomarkers provide information on the
characteristics and extent of cancer progression and help inform clinical decision-making …

Eco-evolutionary dynamics of structured populations in periodically fluctuating environments: a G function approach

A Bukkuri - Theory in Biosciences, 2024 - Springer
Understanding the ecological and evolutionary dynamics of populations is critical for both
basic and applied purposes in a variety of biological contexts. Although several modeling …