Exosomes as mediators of intercellular crosstalk in metabolism

R Isaac, FCG Reis, W Ying, JM Olefsky - Cell metabolism, 2021 - cell.com
Exosomes are nanoparticles secreted by all cell types and are a large component of the
broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted …

A review of exosomal isolation methods: is size exclusion chromatography the best option?

K Sidhom, PO Obi, A Saleem - International journal of molecular sciences, 2020 - mdpi.com
Extracellular vesicles (EVs) are membranous vesicles secreted by both prokaryotic and
eukaryotic cells and play a vital role in intercellular communication. EVs are classified into …

Tissue‐derived extracellular vesicles in cancers and non‐cancer diseases: present and future

SR Li, QW Man, X Gao, H Lin, J Wang… - Journal of …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are lipid‐bilayer membrane structures secreted by most cell
types. EVs act as messengers via the horizontal transfer of lipids, proteins, and nucleic …

Extracellular vesicles in blood: sources, effects, and applications

A Alberro, L Iparraguirre, A Fernandes… - International Journal of …, 2021 - mdpi.com
Extracellular vesicles (EVs) are important players for intercellular communication. EVs are
secreted by almost all cell types; they can transfer information between nearby or distant …

Extracellular vesicle secretion is tissue-dependent ex vivo and skeletal muscle myofiber extracellular vesicles reach the circulation in vivo

AL Estrada, ZJ Valenti, G Hehn… - … of Physiology-Cell …, 2022 - journals.physiology.org
Extracellular vesicles (EVs) are biomarkers and modifiers of human disease. EVs secreted
by insulin-responsive tissues like skeletal muscle (SkM) and white adipose tissue (WAT) …

The impact of obesity on adipocyte-derived extracellular vesicles

HY Kwan, M Chen, K Xu, B Chen - Cellular and Molecular Life Sciences, 2021 - Springer
Recently, the emerging roles of adipocyte-derived extracellular vesicles (EVs) linking
obesity and its comorbidities have been recognized. In obese subjects, adipocytes are …

[HTML][HTML] Perivascular adipose tissue–derived extracellular vesicle miR-221-3p mediates vascular remodeling

X Li, LL Ballantyne, Y Yu, CD Funk - The FASEB Journal, 2019 - ncbi.nlm.nih.gov
Adipose tissue–secreted extracellular vesicles (EVs) containing microRNAs (miRNAs)
convey intercellular message signaling. The biogenesis of EV-miRNAs from perivascular …

Adipose-derived extracellular vesicles: systemic messengers and metabolic regulators in health and disease

ST Bond, AC Calkin, BG Drew - Frontiers in Physiology, 2022 - frontiersin.org
Adipose tissue is comprised of a heterogeneous population of cells that co-operate to
perform diverse physiological roles including endocrine-related functions. The endocrine …

Proteome characterisation of extracellular vesicles isolated from heart

B Claridge, A Rai, H Fang, A Matsumoto, J Luo… - …, 2021 - Wiley Online Library
Cardiac intercellular communication is critical for heart function and often dysregulated in
cardiovascular diseases. While cardiac extracellular vesicles (cEVs) are emerging …

Intercellular and interorgan crosstalk through adipocyte extracellular vesicles

C Crewe, PE Scherer - Reviews in Endocrine and Metabolic Disorders, 2022 - Springer
Functional adipose tissue is essential for homeostatic maintenance of systemic metabolism.
As such, adipose tissue dysfunction, like that seen in the obese state, directly contributes to …