Cytokine storm
DC Fajgenbaum, CH June - New England Journal of Medicine, 2020 - Mass Medical Soc
Cytokine Storm Cytokine storm, a life-threatening disorder involving cytokine elevations and
immune-cell hyperactivation, has various causes and is characterized by constitutional …
immune-cell hyperactivation, has various causes and is characterized by constitutional …
Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?
B Liu, M Li, Z Zhou, X Guan, Y Xiang - Journal of autoimmunity, 2020 - Elsevier
The emergent outbreak of coronavirus disease 2019 (COVID-19) has caused a global
pandemic. Acute respiratory distress syndrome (ARDS) and multiorgan dysfunction are …
pandemic. Acute respiratory distress syndrome (ARDS) and multiorgan dysfunction are …
Recommendations for the management of hemophagocytic lymphohistiocytosis in adults
Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome
induced by aberrantly activated macrophages and cytotoxic T cells. The primary (genetic) …
induced by aberrantly activated macrophages and cytotoxic T cells. The primary (genetic) …
[HTML][HTML] Immune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome
Background T cell mediated hyperinflammatory responses such as cytokine release
syndrome (CRS) and immune effector cell associated neurotoxicity syndrome (ICANS) are …
syndrome (CRS) and immune effector cell associated neurotoxicity syndrome (ICANS) are …
Pediatric hemophagocytic lymphohistiocytosis
SW Canna, RA Marsh - Blood, The Journal of the American …, 2020 - ashpublications.org
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome describing patients with severe
systemic hyperinflammation. Characteristic features include unremitting fever, cytopenias …
systemic hyperinflammation. Characteristic features include unremitting fever, cytopenias …
Emapalumab in children with primary hemophagocytic lymphohistiocytosis
Background Primary hemophagocytic lymphohistiocytosis is a rare syndrome characterized
by immune dysregulation and hyperinflammation. It typically manifests in infancy and is …
by immune dysregulation and hyperinflammation. It typically manifests in infancy and is …
Confirmed efficacy of etoposide and dexamethasone in HLH treatment: long-term results of the cooperative HLH-2004 study
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory
syndrome comprising familial/genetic HLH (FHL) and secondary HLH. In the HLH-94 study …
syndrome comprising familial/genetic HLH (FHL) and secondary HLH. In the HLH-94 study …
Histiocytic disorders
KL McClain, C Bigenwald, M Collin… - Nature Reviews …, 2021 - nature.com
The historic term 'histiocytosis' meaning 'tissue cell'is used as a unifying concept for
diseases characterized by pathogenic myeloid cells that share histological features with …
diseases characterized by pathogenic myeloid cells that share histological features with …
Hemophagocytic lymphohistiocytosis: an update on pathogenesis, diagnosis, and therapy
G Griffin, S Shenoi, GC Hughes - Best Practice & Research Clinical …, 2020 - Elsevier
Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening state of immune
hyperactivation that arises in the setting of genetic mutations and infectious, inflammatory, or …
hyperactivation that arises in the setting of genetic mutations and infectious, inflammatory, or …
Adult haemophagocytic syndrome
Haemophagocytic syndromes (haemophagocytic lymphohistiocytosis) have a wide range of
causes, symptoms, and outcomes, but all lead to a hyperinflammatory response and organ …
causes, symptoms, and outcomes, but all lead to a hyperinflammatory response and organ …