When platelet numbers are low or when their function is disabled, the risk of bleeding is
high, which on the one hand indicates that in normal life vascular damage is a rather …

Platelet activation occurs in response to vessel injury and is important for the arrest of
bleeding. Platelet activation during disease states leads to vascular occlusion and ischemic …

The P2Y12 receptor is a key player in platelet activation and a major target for antithrombotic
drugs. The beneficial effects of P2Y12 receptor antagonists might, however, not be restricted …

Abstract P2Y12, the Gi-coupled platelet receptor for adenosine diphosphate (ADP), plays a
central role in platelet function. Patients with congenital P2Y12 defects display a mild to …

[Frontiers in Bioscience 11, 1977-1986, May 1, 2006] 1977 The role of ADP receptors in platelet
function Swaminathan Murugappan Page 1 [Frontiers in Bioscience 11, 1977-1986, May 1 …

The P2Y 12 receptor is a key player in platelet activation and represents an effective
pharmacological target for the inhibition of platelet aggregation and prevention of …

Prior studies have shown that PI3Ks play a necessary but incompletely defined role in
platelet activation. One potential effector for PI3K is the serine/threonine kinase, Akt, whose …

Upon injury to a vessel wall the exposure of subendothelial collagen results in the activation
of platelets. Platelet activation culminates in shape change, aggregation, release of granule …

Activation of P2Y1 and P2Y12 receptors, through secreted ADP that is stimulated by
agonists such as thrombin, thromboxane and collagen, is a major mechanism of platelet …

Platelets possess two receptors for ADP, P2Y1 and P2Y12. ADP is released from platelet
dense granules upon platelet activation by numerous agonists and thereby amplifies platelet …