Azo molecules possess the characteristic azo bond (-N= N-) and are considered fascinating
motifs in organic chemistry. Since the last century, these brightly colored compounds have …

Azoreductases reductively cleave azo linkages by using NAD (P) H as an electron donor.
The enzymes are widely found in bacteria and act on numerous azo dyes, which allow …

The large intestine is the final section of the gastrointestinal tract (GIT) and consists of the
caecum, colon, rectum, anal canal, and anus. The colon is the longest portion of the large …

The gut microbiota plays an important role in regulating the pharmacokinetics and
pharmacodynamics of many drugs. FLZ, a novel squamosamide derivative, has been shown …

Azo dyes are extremely important in variety of industries for variety of technical purposes.
The compounds containing azo grouping are most widely used as synthetic colorants. Azo …

Objective (s): This study is aimed to design and synthesize a prodrug of 5-aminosalicylic
acid and evaluate its ameliorative effect on experimental ulcerative colitis (UC). Materials …

2-(4-Chlorophenyl)-5-benzoxazoleacetic acid (CBA) and its ester, methyl-2-(4-chloro-
phenyl)-5-benzoxazoleacetate (MCBA), were synthesized, and their structures were …

The discovery of a multi-target scaffold in medicinal chemistry is an important goal for the
development of new drugs with different biological effects. Azobenzene is one of the …

SARS-CoV-2, the virus responsible for COVID-19, is constantly evolving, leading to the
emergence of new variants such as Omicron, which is currently dominant worldwide [1] …

This review encapsulates an extensive variety of substances identified as mutual prodrugs
or codrugs, wherein two, or sometimes three, biologically active moieties are linked using an …