The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

Histone acetylation is a prominent epigenetic modification of the central nervous system that
is unequivocally associated with an increase in the rate of gene transcription. Because gene …

Nonspecific histone deacetylase (HDAC) inhibition has been shown to facilitate the
extinction of drug-seeking behavior in a manner resistant to reinstatement. A key open …

Gene expression is dynamically regulated by chromatin modifications on histone tails, such
as acetylation. In general, histone acetylation promotes transcription, whereas histone …

Histone deacetylase (HDAC) inhibitors increase histone acetylation and enhance both
memory and synaptic plasticity. The current model for the action of HDAC inhibitors assumes …

The orphan nuclear receptors NR4A1, NR4A2 and NR4A3 are immediate early genes
induced by multiple stressors, and the NR4A receptors play an important role in maintaining …

Following surgery, elderly patients often suffer from postoperative cognitive dysfunction
(POCD) which can persist long after physical recovery. It is known that surgery-induced …

NR4A2 is a nuclear receptor and a transcription factor, with distinctive physiological
features. In the cell nuclei of the central nervous system, it is widely expressed and identified …

Introduction: Prolonged inflammatory response contributes to the pathogenesis of chronic
disease-related disturbances. Among nuclear receptors (NRs), the orphan NR4A subfamily …

The formation of a long-lasting memory requires a transcription-dependent consolidation
period that converts a short-term memory into a long-term memory. Nuclear receptors …