The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

Tight junctions (TJ) play a central role in the homeostasis of epithelial and endothelial
tissues, by providing a semipermeable barrier to ions and solutes, by contributing to the …

Vascular endothelial cells (ECs) form a semiselective barrier for macromolecules and cell
elements regulated by dynamic interactions between cytoskeletal elements and cell …

Inflammatory mediators increase vascular permeability primarily by formation of intercellular
gaps between endothelial cells of post-capillary venules. Under these conditions …

cAMP is a second messenger that is essential for relaying hormonal responses in many
biological processes. The discovery of the cAMP target Epac explained various effects of …

Rho kinases (ROCKs) are the first and the best-characterized effectors of the small G-protein
RhoA. In addition to their effect on actin organization, or through this effect, ROCKs have …

Skeletal muscle insulin resistance is the earliest defect in type 2 diabetes (T2D), preceding
and predicting disease development. To what extent this reflects a primary defect or is …

The RhoA GTPase plays a vital role in assembly of contractile actin-myosin filaments (stress
fibers) and of associated focal adhesion complexes of adherent monolayer cells in culture …

Endothelium forms a semi-permeable barrier that separates blood from the underlying
tissue. Barrier function is largely determined by cell-cell and cell-matrix adhesions that …

Purpose MMP9 is a matricellular protein associated with extracellular matrix (ECM)
remodelling, that promotes tumour progression, and modulates the activity of cell adhesion …