miRNAs in cancer (review of literature)

B Smolarz, A Durczyński, H Romanowicz… - International journal of …, 2022 - mdpi.com
MicroRNAs (miRNAs) are short, noncoding, single-stranded RNA molecules that regulate
gene expression at the post-transcriptional level by binding to mRNAs. miRNAs affect the …

Circular RNA participates in the carcinogenesis and the malignant behavior of cancer

ZJ Zhao, J Shen - RNA biology, 2017 - Taylor & Francis
Circular RNAs (circRNAs) are long, non-coding RNAs that result from the non-canonical
splicing of linear pre-mRNAs. However, the characteristics and the critical role of circRNA in …

A uniform system for the annotation of vertebrate microRNA genes and the evolution of the human microRNAome

B Fromm, T Billipp, LE Peck, M Johansen… - Annual review of …, 2015 - annualreviews.org
Although microRNAs (miRNAs) are among the most intensively studied molecules of the
past 20 years, determining what is and what is not a miRNA has not been straightforward …

Synthetic circular RNA functions as a miR-21 sponge to suppress gastric carcinoma cell proliferation

X Liu, JM Abraham, Y Cheng, Z Wang, Z Wang… - … Therapy-Nucleic Acids, 2018 - cell.com
MicroRNA (miR) sponges containing miR binding sequences constitute a potentially
powerful molecular therapeutic strategy. Recently, naturally occurring circular RNAs …

[HTML][HTML] Circular RNAs in cancer: novel insights into origins, properties, functions and implications

J Li, J Yang, P Zhou, Y Le, C Zhou, S Wang… - American journal of …, 2015 - ncbi.nlm.nih.gov
Circular RNAs (circRNAs) are a large class of RNAs that, unlike linear RNAs, form covalently
closed continuous loops and have recently shown huge capabilities as gene regulators in …

Breast cancer; discovery of novel diagnostic biomarkers, drug resistance, and therapeutic implications

S Afzal, M Hassan, S Ullah, H Abbas… - Frontiers in molecular …, 2022 - frontiersin.org
Breast cancer is the second most reported cancer in women with high mortality causing
millions of cancer-related deaths annually. Early detection of breast cancer intensifies the …

miRNA therapeutics: a new class of drugs with potential therapeutic applications in the heart

BC Bernardo, JYY Ooi, RCY Lin… - Future medicinal …, 2015 - Taylor & Francis
miRNAs are small non-coding RNAs (ncRNAs), which regulate gene expression. Here, the
authors describe the contribution of miRNAs to cardiac biology and disease. They discuss …

[HTML][HTML] Interplay between microRNAs and WNT/β-catenin signalling pathway regulates epithelial–mesenchymal transition in cancer

NM Ghahhari, S Babashah - European journal of cancer, 2015 - Elsevier
The WNT/β-catenin signalling implies its significance in maintaining an epithelial cell
phenotype, proper cell–cell junctions, and tissue homeostasis. Dysregulation of the …

Engineered circular RNA sponges act as miRNA inhibitors to attenuate pressure overload-induced cardiac hypertrophy

A Lavenniah, TDA Luu, YP Li, TB Lim, J Jiang… - Molecular Therapy, 2020 - cell.com
Circular RNAs (circRNAs) sequester microRNAs (miRNAs) and repress their endogenous
activity. We hypothesized that artificial circRNA sponges (circmiRs) can be constructed to …

Circular RNAs: a new frontier for cancer diagnosis and therapy

M Zhang, Y Xin - Journal of hematology & oncology, 2018 - Springer
In recent years, circular RNAs (circRNAs) have attracted considerable attention because
they play a significant role in many fields of cancer biology. Additionally, it has become …