Gut–Liver axis and non-alcoholic fatty liver disease: A vicious circle of dysfunctions orchestrated by the gut microbiome

S Pezzino, M Sofia, G Faletra, C Mazzone, G Litrico… - Biology, 2022 - mdpi.com
Simple Summary Non-alcoholic fatty liver disease (NAFLD) is a widespread disease
associated with metabolic disorders, such as obesity. In recent years, there has been …

The nutrition-microbiota-physical activity triad: an inspiring new concept for health and sports performance

N Boisseau, N Barnich, C Koechlin-Ramonatxo - Nutrients, 2022 - mdpi.com
The human gut microbiota is currently the focus of converging interest in many diseases and
sports performance. This review presents gut microbiota as a real “orchestra conductor” in …

Balancing the Equation: A Natural History of Trimethylamine and Trimethylamine-N-oxide

RL Loo, Q Chan, JK Nicholson… - Journal of Proteome …, 2022 - ACS Publications
Trimethylamine (TMA) and its N-oxide (TMAO) are ubiquitous in prokaryote and eukaryote
organisms as well as in the environment, reflecting their fundamental importance in …

Dietary choline increases brown adipose tissue activation markers and improves cholesterol metabolism in female APOE*3-Leiden.CETP mice

C Liu, Z Song, Z Li, MR Boon, M Schönke… - International Journal of …, 2023 - nature.com
Objectives Studies in mice have recently linked increased dietary choline consumption to
increased incidence of obesity-related metabolic diseases, while several clinical trials have …

Gut matters in microgravity: potential link of gut microbiota and its metabolites to cardiovascular and musculoskeletal well-being

Z Ibrahim, NA Khan, R Siddiqui, R Qaisar… - Nutrition & …, 2024 - Springer
The gut microbiota and its secreted metabolites play a significant role in cardiovascular and
musculoskeletal health and diseases. The dysregulation of the intestinal microbiota poses a …

Gut metabolite trimethylamine N-oxide protects INS-1 β-cell and rat islet function under diabetic glucolipotoxic conditions

ES Krueger, JL Beales, KB Russon, WS Elison… - Biomolecules, 2021 - mdpi.com
Serum accumulation of the gut microbial metabolite trimethylamine N-oxide (TMAO) is
associated with high caloric intake and type 2 diabetes (T2D). Impaired pancreatic β-cell …

The gut microbiota metabolite trimethylamine-N-oxide in children with β-thalassemia: potential implication for iron-induced renal tubular dysfunction

AA Ghalwash, RM El-Gohary, D El Amrousy… - Pediatric …, 2024 - nature.com
Background Renal tubular dysfunction is common in transfusion-dependent β thalassemia
(β-TM). Iron overload, chronic anemia, and hypoxia are precipitating factors for renal insult …

Gut microbiota and childhood malnutrition: Understanding the link and exploring therapeutic interventions

S Zoghi, F Sadeghpour Heravi… - Engineering in Life …, 2024 - Wiley Online Library
Childhood malnutrition is a metabolic condition that affects the physical and mental well‐
being of children and leads to resultant disorders in maturity. The development of childhood …

Might Gut Microbiota Be a Target for a Personalized Therapeutic Approach in Patients Affected by Atherosclerosis Disease?

MM Ciccone, ME Lepera, AI Guaricci, C Forleo… - Journal of Personalized …, 2023 - mdpi.com
In recent years, the increasing number of studies on the relationship between the gut
microbiota and atherosclerosis have led to significant interest in this subject. The gut …

Impacts of maternal microbiota and microbial metabolites on fetal intestine, brain, and placenta

A Husso, T Pessa-Morikawa, VM Koistinen… - BMC biology, 2023 - Springer
Background The maternal microbiota modulates fetal development, but the mechanisms of
these earliest host-microbe interactions are unclear. To investigate the developmental …