High-fat, low-carbohydrate diets, known as ketogenic diets, have been used as a non-
pharmacological treatment for refractory epilepsy. A key mechanism of this treatment is …

Antiseizure drugs (ASDs), also termed antiepileptic drugs, are the main form of symptomatic
treatment for people with epilepsy, but not all patients become free of seizures. The …

Abstract See Rogawski (doi: 10.1093/awv369) for a scientific commentary on this article. The
medium chain triglyceride ketogenic diet is an established treatment for drug-resistant …

The high-fat ketogenic diet (KD) is a remarkably effective treatment for medically intractable
epilepsy and has been part of the clinical armamentarium for nearly a century. However, the …

Ethics on animal use in science in Western society is based on utilitarianism, weighing the
harms and benefits to the animals involved against those of the intended human …

Neurons have highly developed Ca 2+ signalling systems responsible for regulating many
neural functions such as the generation of brain rhythms, information processing and the …

Summary The Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT
XIV) took place in Madrid, Spain, on May 13‐16, 2018 and was attended by 168 delegates …

The medium chain triglyceride (MCT) ketogenic diet is used extensively for treating
refractory childhood epilepsy. This diet increases the plasma levels of medium straight chain …

The availability of animal models of epileptic seizures provides opportunities to identify
novel anticonvulsants for the treatment of people with epilepsy. We found that exposure of 2 …

Despite appropriate antiepileptic drug treatment, approximately one-third of humans and
dogs with epilepsy continue experiencing seizures, emphasising the importance for new …