The discovery of new therapeutic drugs is heavily reliant on the structural diversity and
pharmacological properties of heterocyclic compounds. Pyridine heterocyclic‐related …

Abstract New 5‐cyano‐6‐oxo‐pyridine‐based sulfonamides (6a–m and 8a–d) were
designed and synthesized to potentially inhibit both the epidermal growth factor receptor …

New series of substituted 2-alkoxycyanopyridine derivatives were synthesized and
evaluated for their in vitro and in vivo anticancer activities. Comparing the evaluated …

2-((3-Cyano-4, 6-dimethylpyridin-2-yl) oxy) acetohydrazide 1 was used as the precursor for
the synthesis of 5-thioxo-1, 3, 4-oxadiazol-2-yl) methoxy) nicotinonitrile 2. The latter was …

Cancer involves the uncontrolled, abnormal growth of cells and affects other tissues. Kinase
has an impact on proliferating the cells and causing cancer. For the purpose of treating …

Thirteen diarylurea derivatives were designed and synthesized as sorafenib mimetics. The
cytotoxic activity of the newly synthesized entities towards human breast cancer cell …

A novel series of cyanopyridines 7a-j were synthesized via a one-pot multicomponent
reaction of arylidene 4 with ammonium acetate 5 and respective methylaryl/heterylketones …

Introduction: PIM kinases are targets for therapeutic intervention since they are associated
with a number of malignancies by boosting cell survival and proliferation. Over the past …

This study involved designing and synthesizing new derivatives of pyrazolo [1, 5-a]
pyrimidine 5a-l, which were prepared via reaction of 4-Arylazo-1H-pyrazole-3, 5-diamines …

One of the most perilous illnesses in the world is cancer. The cancer may be associated with
the mutation of different genes inside the body. The PIM kinase, also known as the …