Background Early diagnosis and treatment of juvenile idiopathic arthritis (JIA) with
conventional and biologic disease-modifying anti-rheumatic drugs have vastly improved …

Background Biologic disease-modifying antirheumatic drugs (bDMARDs) have changed the
treatment of juvenile idiopathic arthritis (JIA) patients notably, as bDMARDs enable …

DEK protein is critical to the formation of neutrophil extracellular traps (NETs) in rheumatoid
arthritis (RA). Blocking DEK using the aptamer DTA via articular injection has been shown to …

Objective Conventional immunoassays detect autoantibodies related to systemic lupus
erythematosus (SLE) via recognition of epitopes on autoantigens expressed in their …

JIA is a heterogenous disease for which prospective clinical trials are needed to address the
question of when, how, and in whom to withdraw medication. Research investigating the …

Background: Juvenile idiopathic arthritis (JIA) is the most common chronic inflammatory
arthritis of childhood, characterized by various clinical phenotypes associated with variable …

Objective Anti–histidyl‐transfer RNA synthetase (Jo‐1) antibodies are associated with
myositis as well as different extramuscular organ complications comprising the anti …

Poly (ADP-ribosyl) ation plays a key role in cellular metabolism. Covalent poly (ADP-ribosyl)
ation affects the activity of the proteins engaged in DNA repair, chromatin structure …

In this issue of the JCI, Capitano et al. demonstrate that the secreted form of the DNA-
binding chromatin factor DEK regulates hematopoiesis. It is known that DEK can be secreted …

Поли (АDP-рибозил) ирование играет важнейшую роль в клеточном метаболизме.
Ковалентное поли (АDP-рибозил) ирование влияет на работу белков, вовлеченных в …