Molecules | Free Full-Text | 4-Aryldihydropyrimidines via the Biginelli Condensation: Aza-Analogs
of Nifedipine-Type Calcium Channel Modulators Next Article in Journal Synthesis and …

In continuation to our previous work, thiazolopyrimidines 2a–x were synthesized through
intramolecular cyclization of 2-phenacylthio-dihydropyrimidine hydrobromides 1a–x using …

The cyclocondensation of suitable CH‐acidic carbonyl compounds, aldehydes, and urea‐
type blocks under acidic conditions provides multifunctionalized derivatives. The discovery …

Four pyridine-pyrimidine derivatives, namely pyridine-2, 6-diamine (PD), pyrimidine-2-amine
(PA), 6-amino-3, 4-dihydropyrimidine-2 (1H)-thione (ADT) and ethyl (R)-6-(4-chlorophenyl) …

A new series of triazolopyrimidines and thiazolopyrimidine hydrobromides was designed
and prepared as topoisomerase II inhibitors. Screening of all synthesized compounds was …

An efficient one-pot synthesis of 5-acyl-1, 2, 3, 4-tetrahydropyrimidine-2-thiones/ones is
described. The synthesis is based on the reaction of readily available α-tosyl substituted …

CDC25 inhibition by thiazolopyrimidines: CDC25 is an attractive target for cancer therapy,
as it is overexpressed in numerous cancers and is often associated with tumor …

Biginelli reactions were performed using either ZrCl4 or ZrOCl2· 8H2O as catalysts under
neat conditions. Shorter reaction time than most of the classical methods was required when …

Chlorosulfonation of 3-methyl [1, 2, 4] triazolo [4, 3-a] pyrimidine with chlorosulfonic acid in
the presence of thionyl chloride was studied. When triazolo [4, 3-a] pyrimidines are used as …

Abstract Inhibition of phosphodiesterase-5 (PDE5) has been validated as possible new
therapeutic approach for cancer. To further explore this concept, three series of …