Abstract More than 2.1 million age-related fractures occur in the United States annually,
resulting in an immense socioeconomic burden. Importantly, the age-related deterioration of …

Imbalance of bone homeostasis, with excessive bone resorption compared with bone
formation, leads to the development of progressive osteopenia leading to lower bone …

Senescent cells have detrimental effects across tissues with aging but may have beneficial
effects on tissue repair, specifically on skin wound healing. However, the potential role of …

The immune system and skeletal system are closely linked. Macrophages are one of the
most important immune cells for bone remodeling, playing a prohealing role mainly through …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in
severe damage to the respiratory system. With no specific treatment to date, it is crucial to …

Inflammatory pain serves as a protective defense mechanism which becomes pathological
when it turns into chronic inflammatory pain. This transition is mediated by a variety of …

Ethnopharmacological relevance The active ingredients of traditional Chinese medicine
(TCM), such as naringin (NG), Eucommiol, isopsoralen, icariin, Astragalus polysaccharides …

Background In previous studies, we reported the beneficial impact of two lipoxygenase-
inhibitors, Baicalein and Zileuton, on osteoporotic bone in a postmenopausal rat model …

Context: An altered lipid profile may lead to the development of CVD. Objective: We
evaluated the protective role of baicalein (BAC) against lipidemic and oxidative stress in …

Flavonoids are polyphenolic compounds produced by plants as secondary metabolites that
are known to exhibit wide range of pharmaceutical properties. Flavonoids from different …