Reprogrammed metabolism is a hallmark of colorectal cancer (CRC). CRC cells are geared
toward rapid proliferation, requiring nutrients and the removal of cellular waste in nutrient …

Discriminating the contribution of unmodifiable random intrinsic DNA replication errors ('bad
luck') to cancer development from those of other factors is critical for understanding cancer in …

The imbalance between energy intake and expenditure is the main cause of excessive
overweight and obesity. Technically, obesity is defined as the abnormal accumulation of≥ …

Obesity is an established risk factor for cancer in many tissues. In the mammalian intestine, a
pro-obesity high-fat diet (HFD) promotes regeneration and tumorigenesis by enhancing …

Background/Aims: Elevated serum cholesterol levels were linked to a higher risk of
colorectal adenoma and colorectal cancer (CRC), while the effect of cholesterol on CRC …

Adipose tissue is a highly dynamic endocrine tissue and constitutes a central node in the
interorgan crosstalk network through adipokines, which cause pleiotropic effects, including …

Cholesterol homeostasis has been implicated in the regulation of cellular and body
metabolism. Hence, deregulated cholesterol homeostasis leads to the development of many …

There is compelling epidemiological evidence linking obesity to many tumours; however, the
molecular mechanisms fuelling this association are not clearly understood. Emerging …

Background: Colorectal cancer (CRC) progression and related mortality are highly
associated with metabolic disorders. However, the molecular mechanism involved in the …

Obesity, characterised as a chronic low-grade inflammation is a crucial risk factor for colon
cancer. The expansion of the adipose tissue is related to elevated triglyceride and low …