Alzheimer's disease (AD) is a progressive and synaptic failure disease. Despite the many
years of research, AD still harbors many secrets. As more of the world's population grows …

Altered synaptic structure and function is a major hallmark of fragile X syndrome (FXS),
autism spectrum disorders (ASDs), and other intellectual disabilities (IDs), which are …

Answering the question as to why we age is tantamount to answering the question of what is
life itself. There are countless theories as to why and how we age, but, until recently, the very …

Microglia-mediated synaptic loss contributes to the development of cognitive impairments in
Alzheimer's disease (AD). However, the basis for this immune-mediated attack on synapses …

Objective Currently no effective disease‐modifying agents exist for the treatment of
Alzheimer disease (AD). The Fyn tyrosine kinase is implicated in AD pathology triggered by …

Microglia are the predominant immune response cells and professional phagocytes of the
central nervous system (CNS) that have been shown to be important for brain development …

Learning and memory are associated with the formation and modification of neuronal
assemblies: populations of neurons that encode what has been learned and mediate …

Microglial control of activity‐dependent plasticity and synaptic remodeling in neuronal
networks has been the subject of intense research in the past several years. Although …

Substantial progress has been made toward understanding the neuropathology, genetic
origins, and epidemiology of neurodegenerative diseases, including Alzheimer's disease; …

The appearance and disappearance of dendritic spines, accompanied by synapse formation
and elimination may underlie the experience-dependent reorganization of cortical circuits …