Steroidal saponins: naturally occurring compounds as inhibitors of the hallmarks of cancer

S Bouabdallah, A Al-Maktoum, A Amin - Cancers, 2023 - mdpi.com
Simple Summary Cancer is one of the most life-threatening diseases that affects a rapidly
growing number of individuals worldwide. Currently, chemotherapy is the most common …

Inhibiting angiogenesis by anti-cancer saponins: from phytochemistry to cellular signaling pathways

MB Majnooni, S Fakhri, SM Ghanadian, G Bahrami… - Metabolites, 2023 - mdpi.com
Saponins are one of the broadest classes of high-molecular-weight natural compounds,
consisting mainly of a non-polar moiety with 27 to 30 carbons and a polar moiety containing …

Comprehensive review of Bcl‐2 family proteins in cancer apoptosis: Therapeutic strategies and promising updates of natural bioactive compounds and small …

Iksen, W Witayateeraporn, B Hardianti… - Phytotherapy …, 2024 - Wiley Online Library
Cancer has a considerably higher fatality rate than other diseases globally and is one of the
most lethal and profoundly disruptive ailments. The increasing incidence of cancer among …

Identifying molecular targets of Aspiletrein-derived steroidal saponins in lung cancer using network pharmacology and molecular docking-based assessments

I Iksen, W Witayateeraporn, T Wirojwongchai… - Scientific Reports, 2023 - nature.com
Lung cancer is one of the leading cancers and causes of cancer-related deaths worldwide.
Due to its high prevalence and mortality rate, its clinical management remains a significant …

Advances in antitumor activity and mechanism of natural steroidal saponins: A review of advances, challenges, and future prospects

F Wang, L Liang, M Yu, W Wang, IH Badar, Y Bao… - Phytomedicine, 2024 - Elsevier
Background Cancer, the second leading cause of death worldwide following cardiovascular
diseases, presents a formidable challenge in clinical settings due to the extensive toxic side …

Naturally occurring steroidal saponins as potential anticancer agents: Current developments and mechanisms of action

Y Zou - Current Topics in Medicinal Chemistry, 2022 - ingentaconnect.com
Cancer is claimed as a prevalent cause of mortality throughout the world. Conventional
chemotherapy plays a pivotal role in the treatment of cancers, but multidrug resistance has …

Aspiletrein A induces apoptosis cell death via increasing reactive oxygen species generation and AMPK activation in non-small-cell lung cancer cells

W Witayateeraporn, HM Nguyen, DV Ho… - International Journal of …, 2022 - mdpi.com
Lung cancer remains a leading cause of death in cancer patients, and deregulation of
apoptosis is a serious concern in clinical practice, even though therapeutic intervention has …

Aspidiata E, a New Spirostanol Saponin From Aspidistra triradiata and its Cytotoxic Activity

HBT Le, VAT Tran, HM Nguyen… - Natural Product …, 2023 - journals.sagepub.com
Aspidiata E (1), a new spirostanol saponin {(22 S*, 25 R*)-1 β, 3 β, 4 β, 5 β, 6 β-
pentahydroxyspirostan-2 β-yl β-D-xylopyranoside), together with 2 known compounds,(22 …

Aspidiatas C and D, two new spirostanol saponins from Aspidistra triradiata and their cytotoxic activities

H Bich Thi Le, DV Ho, H Minh Nguyen… - Natural Product …, 2024 - Taylor & Francis
Aspidiatas C and D (1 and 2), two new spirostanol saponins, were isolated along with two
known compounds,(25 R*)-spirost-5-en-3 β-yl α-L-rhamnopyranosyl-(1→ 4)-α-L …

[PDF][PDF] Saponins as anticancer agents: Delving into their mechanisms of action

OZ Akunne - International Journal of Green Pharmacy (IJGP), 2023 - greenpharmacy.info
Saponins as anticancer agents: Delving into their mechanisms of action Page 1
International Journal of Green Pharmacy • Oct-Dec 2023 • 17 (4) | 276 Saponins as …