Antimicrobials are among the most important and commonly prescribed drugs in the
management of critically ill patients and beta-lactams are the most common antibiotic class …

Continuous Renal Replacement Therapy (CRRT) is more and more widely used in patients
for various indications recent years. It is still intricate for clinicians to decide a suitable …

Objective: To summarize current antibiotic dosing recommendations in critically ill patients
receiving intermittent hemodialysis (IHD), prolonged intermittent renal replacement therapy …

What is known and objective Meropenem, a carbapenem antibiotic, is widely prescribed for
the treatment of life‐threatening infections. The main parameter associated with its …

Over the last several decades, antibacterial drug use has become widespread with their
misuse being an ever-increasing phenomenon. Consequently, antibacterial drugs have …

Introduction: The pharmacokinetic/pharmacodynamic index determining β-lactam activity is
the percentage of the dosing interval (% T) during which their free serum concentration …

Rationale: Data suggest that altered antimicrobial concentrations are likely during
extracorporeal membrane oxygenation (ECMO). Objectives: The primary aim of this analysis …

Intensive care unit (ICU) patients with end-organ failure will require specialised machines or
extracorporeal therapies to support the failing organs that would otherwise lead to death …

Objectives: The aim of this study is to describe the in vitro adsorption of anti-infective drugs
onto an extracorporeal cytokine adsorber. Methods: Various anti-infective drugs (β-lactams …

The challenging severity of some infections, especially in critically ill patients, makes the
diffusion of antimicrobial drugs within tissues one of the cornerstones of chemotherapy. The …