Propellanes are a unique class of compounds currently consisting of well over 10 000
representatives, all featuring two more or less inverted tetrahedral carbon atoms that are …

The channel-forming activity of a family of small, hydrophobic integral membrane proteins
termed 'viroporins' is essential to the life cycles of an increasingly diverse range of RNA and …

Introduction As a therapeutic antiviral agent, the clinical application of amantadine (AM) is
limited by the emergence of drug-resistant viruses. To overcome the drug-resistant viruses …

The ongoing threat of seasonal and pandemic influenza to human health requires antivirals
that can effectively supplement existing vaccination strategies. The M2 protein of influenza A …

Influenza virus (IFV) causes periodic global influenza pandemics, resulting in substantial
socioeconomic loss and burden on medical facilities. Yearly variation in the effectiveness of …

Ion channels of viruses (viroporins) represent a common type of protein targets for drugs.
The relative simplicity of channel architecture allows convenient computational modeling …

Amantadine is an antiviral agent, but its clinical use against influenza viruses is limited
because of the emergence of drug-resistant viruses. Thus, there is a need for novel anti …

Influenza viruses are the causative agents for seasonal influenza, which results in
thousands of deaths and millions of hospitalizations each year. Moreover, sporadic …

The V27A mutation confers adamantane resistance on the influenza A matrix 2 (M2) proton
channel and is becoming more prevalent in circulating populations of influenza A virus. We …

The drug Rimantadine binds to two different sites in the M2 protein from influenza A, a
peripheral site and a pore site that is the primary site of efficacy. It remained enigmatic that …