Globally, schistosomiasis threatens more than 700 million lives, mostly children, in poor
localities of tropical and sub-tropical areas with morbidity due to acute and chronic …

A transition metal-free and efficient synthesis of fused azapolycycles via a multicomponent
reaction has been developed using mucohalic acid as a C3 synthon. The reaction promoted …

Schistosomiasis is a poverty-associated tropical disease caused by blood dwelling
trematodes that threaten approximately 10% of the world population. Praziquantel, the sole …

A novel series of pyrido [1, 2-a] benzimidazoles bearing Mannich base side chains and their
metabolites were synthesized and evaluated for in vitro antiplasmodium activity, microsomal …

Metal-free catalyzed intermolecular tandem Michael addition/cyclization has been
developed for the synthesis of benzo [4, 5] imidazo [1, 2-a] pyridines from α …

Schistosomiasis is a neglected disease of poverty that is caused by several species of the
trematode flatworm, Schistosoma. Treatment relies on just one drug, the …

Praziquantel is the only widely available drug to treat schistosomiasis. With very few
candidates currently in the drug development pipeline, there is an urgent need to discover …

We have previously reported on the antischistosomal activity of pyrido [1, 2-a] benzimidazole
(PBI) derivatives. As a follow-up, we designed and prosecuted further structure–activity …

For over three decades, praziquantel (PZQ) has been the mainstay chemotherapy for
prevention and treatment of schistosomiasis. The excessive use of PZQ, coupled with the …

Schistosomiasis is one of the most prevalent parasitic diseases, accounting for heavy
socioeconomical and health burden in endemic countries. The control of this neglected …