In terrestrial vertebrates, bone tissue constitutes the 'osteoimmune'system, which functions
as a locomotor organ and a mineral reservoir as well as a primary lymphoid organ where …

Osteoarthritis (OA) can be regarded as a chronic, painful and degenerative disease that
affects all tissues of a joint and one of the major endpoints being loss of articular cartilage. In …

Rheumatoid arthritis (RA), an autoimmune disease that affects∼ 1% of the human
population, is driven by autoantibodies that target modified self-epitopes, whereas∼ 11% of …

Shortly after the discovery of interleukin 17 (IL-17)-producing CD4+ helper T cells (TH17
cells), it was found that γδ T cells can also secrete large amounts of this pro-inflammatory …

The association between chronic inflammation and increased risk of cardiovascular disease
in rheumatoid arthritis (RA) is well established. In the general population, inflammation is an …

IL-1β is a proinflammatory mediator with roles in innate and adaptive immunity. Here we
show that IL-1β contributes to autoimmune arthritis by inducing osteoclastogenic capacity in …

Abstract The interleukin-17 (IL-17) family consists of six family members (IL-17A–IL-17F) and
all the corresponding receptors have been identified recently. This family is mainly involved …

Summary The interleukin 1 (IL-1) pathway signals through IL-1 receptor type 1 (IL-1R1) and
emerges as a central mediator for systemic inflammation. Aberrant IL-1 signaling leads to a …

Abstract Purpose of Review In the process of bone fracture healing, inflammation is thought
to be an essential process that precedes bone formation and remodeling. We review recent …

Objective The spondyloarthritides (SpA) are a group of rheumatic diseases characterized by
ossification and inflammation of entheseal tissue, the region where tendon attaches to bone …