Carbohydrates or glycans are ubiquitous components of the cell surface which play crucial
biological and structural roles. Sialic acids (Sias) are nine-carbon atoms sugars usually …

Sialic acid, as a component of cell surface glycoconjugates, plays a crucial role in
recognition events. Efficient synthetic methods are necessary for the supply of sialosides in …

Immune checkpoint blockade (ICB) treatment is promising for the clinical therapy of
numerous malignancies. However, most cancer patients rarely benefit from such single …

Ibrutinib (IBR), an irreversible Bruton's tyrosine kinase (BTK) inhibitor, is expected to be a
potent therapeutic modality, given that BTK is overexpressed in tumor-associated …

With the knowledge that the receptors of sialic acid are overexpressed on the surface of
tumor-associated macrophages (TAMs), which play a crucial role in the tumor's progression …

Immune checkpoint inhibitors (ICIs), like monoclonal antibodies of PD-1, CTLA-4, and their
ligands, are effective only in some populations of patients with cancer, because the …

Altered sialylation is generally maintained by a fine balance between sialidases and
sialyltransferases, which plays an essential role during disease pathogenesis. TLR4 is a …

Background Leishmania donovani, belonging to a unicellular protozoan parasite, display
the differential level of linkage-specific sialic acids on their surface. Sialic acids binding …

Doxorubicin (DOX) has a cytotoxic effect on many tumor cells; however, its clinical
application is limited owing to its strong side effects. Although Doxil® reduces the …

Abstract Treatment with sialic acid-octadecylamine (SA-ODA)-modified pixantrone (Pix)
liposomes results in favorable antitumor effects by targeting tumor-associated macrophages …