Transcriptional networks controlling stromal cell differentiation
Stromal progenitors are found in many different tissues, where they play an important role in
the maintenance of tissue homeostasis owing to their ability to differentiate into parenchymal …
the maintenance of tissue homeostasis owing to their ability to differentiate into parenchymal …
Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication
Liver fibrosis is a strong predictor of long-term mortality in individuals with metabolic-
associated fatty liver disease; yet, the mechanisms underlying the progression from the …
associated fatty liver disease; yet, the mechanisms underlying the progression from the …
Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis
Mesenchymal (stromal) stem cells (MSCs) constitute populations of mesodermal multipotent
cells involved in tissue regeneration and homeostasis in many different organs. Here we …
cells involved in tissue regeneration and homeostasis in many different organs. Here we …
[HTML][HTML] Diet-induced circadian enhancer remodeling synchronizes opposing hepatic lipid metabolic processes
Overnutrition disrupts circadian metabolic rhythms by mechanisms that are not well
understood. Here, we show that diet-induced obesity (DIO) causes massive remodeling of …
understood. Here, we show that diet-induced obesity (DIO) causes massive remodeling of …
Lipolysis regulates major transcriptional programs in brown adipocytes
LK Markussen, EA Rondini, OS Johansen… - Nature …, 2022 - nature.com
Abstract β-Adrenergic signaling is a core regulator of brown adipocyte function stimulating
both lipolysis and transcription of thermogenic genes, thereby expanding the capacity for …
both lipolysis and transcription of thermogenic genes, thereby expanding the capacity for …
[HTML][HTML] A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis
Fasting metabolism and immunity are tightly linked; however, it is largely unknown how
immune cells contribute to metabolic homeostasis during fasting in healthy subjects. Here …
immune cells contribute to metabolic homeostasis during fasting in healthy subjects. Here …
The hepatocyte clock and feeding control chronophysiology of multiple liver cell types
Most cells of the body contain molecular clocks, but the requirement of peripheral clocks for
rhythmicity and their effects on physiology are not well understood. We show that deletion of …
rhythmicity and their effects on physiology are not well understood. We show that deletion of …
Circadian REV-ERBs repress E4bp4 to activate NAMPT-dependent NAD+ biosynthesis and sustain cardiac function
The heart is a highly metabolic organ that uses multiple energy sources to meet its demand
for ATP production. Diurnal feeding–fasting cycles result in fluctuations in substrate …
for ATP production. Diurnal feeding–fasting cycles result in fluctuations in substrate …
Transcriptome data are insufficient to control false discoveries in regulatory network inference
Inference of causal transcriptional regulatory networks (TRNs) from transcriptomic data
suffers notoriously from false positives. Approaches to control the false discovery rate (FDR) …
suffers notoriously from false positives. Approaches to control the false discovery rate (FDR) …
Single-cell transcriptome analysis of uniparental embryos reveals parent-of-origin effects on human preimplantation development
L Leng, J Sun, J Huang, F Gong, L Yang, S Zhang… - Cell stem cell, 2019 - cell.com
To investigate the contribution of parental genomes to early embryogenesis, we profiled the
single-cell transcriptomes of human biparental and uniparental embryos systematically from …
single-cell transcriptomes of human biparental and uniparental embryos systematically from …