Association analyses based on false discovery rate implicate new loci for coronary artery disease
Genome-wide association studies (GWAS) in coronary artery disease (CAD) had identified
66 loci at'genome-wide significance'(P< 5× 10− 8) at the time of this analysis, but a much …
66 loci at'genome-wide significance'(P< 5× 10− 8) at the time of this analysis, but a much …
Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis
Osteoporosis is a common disease diagnosed primarily by measurement of bone mineral
density (BMD). We undertook a genome-wide association study (GWAS) in 142,487 …
density (BMD). We undertook a genome-wide association study (GWAS) in 142,487 …
Dissecting human population variation in single-cell responses to SARS-CoV-2
Humans display substantial interindividual clinical variability after SARS-CoV-2 infection,–,
the genetic and immunological basis of which has begun to be deciphered. However, the …
the genetic and immunological basis of which has begun to be deciphered. However, the …
Genome-wide analysis of a model-derived binge eating disorder phenotype identifies risk loci and implicates iron metabolism
Binge eating disorder (BED) is the most common eating disorder, yet its genetic architecture
remains largely unknown. Studying BED is challenging because it is often comorbid with …
remains largely unknown. Studying BED is challenging because it is often comorbid with …
The genetic architecture of appendicular lean mass characterized by association analysis in the UK Biobank study
Appendicular lean mass (ALM) is a heritable trait associated with loss of lean muscle mass
and strength, or sarcopenia, but its genetic determinants are largely unknown. Here we …
and strength, or sarcopenia, but its genetic determinants are largely unknown. Here we …
An empirical investigation into the impact of winner's curse on estimates from Mendelian randomization
T Jiang, D Gill, AS Butterworth… - International journal of …, 2023 - academic.oup.com
Introduction Genetic associations for variants identified through genome-wide association
studies (GWASs) tend to be overestimated in the original discovery data set as, if the …
studies (GWASs) tend to be overestimated in the original discovery data set as, if the …
Symptom-level modelling unravels the shared genetic architecture of anxiety and depression
Depression and anxiety are highly prevalent and comorbid psychiatric traits that cause
considerable burden worldwide. Here we use factor analysis and genomic structural …
considerable burden worldwide. Here we use factor analysis and genomic structural …
Synaptic and transcriptionally downregulated genes are associated with cortical thickness differences in autism
Differences in cortical morphology—in particular, cortical volume, thickness and surface
area—have been reported in individuals with autism. However, it is unclear what aspects of …
area—have been reported in individuals with autism. However, it is unclear what aspects of …
Genome-wide meta-analysis of cognitive empathy: heritability, and correlates with sex, neuropsychiatric conditions and cognition
We conducted a genome-wide meta-analysis of cognitive empathy using the 'Reading the
Mind in the Eyes' Test (Eyes Test) in 88,056 research volunteers of European Ancestry …
Mind in the Eyes' Test (Eyes Test) in 88,056 research volunteers of European Ancestry …
Association analyses identify 31 new risk loci for colorectal cancer susceptibility
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a
strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases …
strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases …