Role of animal models in biomedical research: a review

P Mukherjee, S Roy, D Ghosh, SK Nandi - Laboratory Animal Research, 2022 - Springer
The animal model deals with the species other than the human, as it can imitate the disease
progression, its' diagnosis as well as a treatment similar to human. Discovery of a drug …

Defining pulsatility during continuous-flow ventricular assist device support

KG Soucy, SC Koenig, GA Giridharan… - The Journal of Heart and …, 2013 - Elsevier
Continuous-flow ventricular assist devices (CVADs) have gained widespread use as an
effective clinical therapy for patients with advanced-stage heart failure. Axial and centrifugal …

Rotary pumps and diminished pulsatility: do we need a pulse?

KG Soucy, SC Koenig, GA Giridharan… - aSaiO …, 2013 - journals.lww.com
Ventricular assist devices (VADs) have been successfully used as a bridge to heart
transplant and destination therapy (DT) for congestive heart failure (HF) patients. Recently …

Left ventricular assist device-induced reverse remodeling: it's not just about myocardial recovery

KK Marinescu, N Uriel, DL Mann… - Expert review of medical …, 2017 - Taylor & Francis
Introduction: The abnormal structure, function and molecular makeup of dilated
cardiomyopathic hearts can be partially normalized in patients supported by a left ventricular …

Effect of the pulsatile extracorporeal membrane oxygenation on hemodynamic energy and systemic microcirculation in a piglet model of acute cardiac failure

H Itoh, S Ichiba, Y Ujike, T Douguchi, H Obata… - Artificial …, 2016 - Wiley Online Library
The objective of this study was to compare the effects of pulsatile and nonpulsatile
extracorporeal membrane oxygenation (ECMO) on hemodynamic energy and systemic …

Efficacy and safety of ECG‐synchronized pulsatile extracorporeal membrane oxygenation in the clinical setting: The SynCor Trial

I Voigt, T Spangenberg, T Ibrahim, C Bradaric… - Artificial …, 2022 - Wiley Online Library
Introduction Mechanical circulatory support (MCS) devices are increasingly used as a
treatment option in resuscitation or in patients with cardiogenic shock (CS). Prophylactic …

In vivo hemodynamic performance evaluation of novel electrocardiogram‐synchronized pulsatile and nonpulsatile extracorporeal life support systems in an adult …

S Wang, JM Izer, JB Clark, S Patel, L Pauliks… - Artificial …, 2015 - Wiley Online Library
The primary objective of this study was to evaluate a novel electrocardiogram (ECG)‐
synchronized pulsatile extracorporeal life support (ECLS) system for adult partial …

Exercise performance of chronic heart failure patients in the early period of support by an axial‐flow left ventricular assist device as destination therapy

L Compostella, N Russo, T Setzu… - Artificial …, 2014 - Wiley Online Library
Axial‐flow left ventricular assist devices (LVAD s) are increasingly used as destination
therapy in end‐stage chronic heart failure (CHF), as they improve survival and quality of life …

Minimizing left ventricular stroke work with iterative learning flow profile control of rotary blood pumps

D Rüschen, F Prochazka, R Amacher… - … Signal Processing and …, 2017 - Elsevier
Rotary blood pumps are gaining importance in the successful treatment of advanced heart
failure. However, the application of fixed pump speeds is discussed controversially. Since …

Pulsatile venoarterial perfusion using a novel synchronized cardiac assist device augments coronary artery blood flow during ventricular fibrillation

B Cremers, A Link, C Werner, H Gorhan… - Artificial …, 2015 - Wiley Online Library
Patients with cardiogenic shock have a very high mortality. Here we report the first use of a
percutaneous pulsatile cardiac assist device, based on a diagonal pump synchronized with …