Alveolar hypoxia is the most prominent feature of high altitude environment with well-known
consequences for the cardio-pulmonary system, including development of pulmonary …

Non-anaemic iron deficiency (NAID) is a strategic target in cardiovascular medicine because
of its association with a range of adverse effects in various conditions. Endeavours to tackle …

Iron deficiency augments hypoxic pulmonary arterial pressure in healthy individuals and
exacerbates pulmonary arterial hypertension (PAH) in patients, even without anemia …

In patients affected by Acute Respiratory Distress Syndrome (ARDS), Chronic Obstructive
Pulmonary Disease (COPD) and Coronavirus Disease 2019 (COVID-19), unclear …

The unique property of the pulmonary circulation to constrict in response to hypoxia, rather
than dilate, brings advantages in both health and disease. Hypoxic pulmonary …

Key points Iron acts as a cofactor in the stabilization of the hypoxic‐inducible factor family,
and plays an influential role in the modulation of hypoxic pulmonary vasoconstriction. It is …

Pulmonary arterial hypertension (PAH) is a severe cardiovascular disease that is caused by
the progressive occlusion of the distal pulmonary arteries, eventually leading to right heart …

Hypoxia, or lack of oxygen, can occur in both physiological (high altitude) and pathological
conditions (respiratory diseases). In this narrative review, we introduce high altitude …

It is proposed that the mechanistic basis for non-neoplastic lung injury with cigarette
smoking is a disruption of iron homeostasis in cells after exposure to cigarette smoke …

Background Increased iron availability modifies cardiorespiratory function in healthy
volunteers and improves exercise capacity and quality of life in patients with heart failure or …