The complement system is recognised as a protector against blood-borne pathogens and a
controller of immune system and tissue homoeostasis. However, dysregulated complement …

The complement system was discovered at the end of the 19th century as a heat-labile
plasma component that “complemented” the antibodies in killing microbes, hence the name …

The ability of the complement system to rapidly and broadly react to microbial intruders,
apoptotic cells and other threats by inducing forceful elimination responses is indispensable …

Endometriosis (EM) is a chronic disease characterized by the presence and proliferation of
functional endometrial glands and stroma outside the uterine cavity. Ovaries and pelvic …

Paroxysmal nocturnal haemoglobinuria (PNH) is characterized by complement‐mediated
intravascular haemolysis, severe thrombophilia and bone marrow failure. While for patients …

Complement is an elaborate system of innate immunity. Genetic variants and autoantibodies
leading to excessive complement activation are implicated in a variety of human diseases …

The renaissance of complement diagnostics and therapeutics has introduced precision
medicine into a widened field of complement-mediated diseases. In particular, complement …

Crovalimab, a novel C5 inhibitor, allows for low‐volume, every‐4‐week, subcutaneous self‐
administration. COMMODORE 1 (NCT04432584) is a phase 3, global, randomized trial …

In the last decade, a deeper understanding of the pathogenesis of complement mediated
hemolytic disorders, such as paroxysmal nocturnal hemoglobinuria (PNH), cold agglutinin …

ABSTRACT A refined understanding of the role of complement in the pathogenesis of
glomerular and other kidney diseases has, over the past two decades, been matched by the …