The cellular and molecular basis of major depressive disorder: towards a unified model for understanding clinical depression

E Pitsillou, SM Bresnehan, EA Kagarakis… - Molecular biology …, 2020 - Springer
Major depressive disorder (MDD) is considered a serious public health issue that adversely
impacts an individual's quality of life and contributes significantly to the global burden of …

Context-dependent role of NF-κB signaling in primary liver cancer—from tumor development to therapeutic implications

C Czauderna, D Castven, FL Mahn, JU Marquardt - Cancers, 2019 - mdpi.com
Chronic inflammatory cell death is a major risk factor for the development of diverse cancers
including liver cancer. Herein, disruption of the hepatic microenvironment as well as the …

[HTML][HTML] MicroRNA-26a/death-associated protein kinase 1 signaling induces synucleinopathy and dopaminergic neuron degeneration in Parkinson's disease

Y Su, MF Deng, W Xiong, AJ Xie, J Guo, ZH Liang… - Biological …, 2019 - Elsevier
Background Death-associated protein kinase 1 (DAPK1) is a widely distributed
serine/threonine kinase that is critical for cell death in multiple neurological disorders …

Defining the spatial-molecular map of fibrotic tendon healing and the drivers of Scleraxis-lineage cell fate and function

JE Ackerman, KT Best, SN Muscat, EM Pritchett… - Cell reports, 2022 - cell.com
Tendon injuries heal via a scar-mediated response, and there are no biological approaches
to promote more regenerative healing. Mouse flexor tendons heal through the formation of …

RelA/p65 inhibition prevents tendon adhesion by modulating inflammation, cell proliferation, and apoptosis

S Chen, S Jiang, W Zheng, B Tu, S Liu, H Ruan… - Cell death & …, 2017 - nature.com
Peritendinous tissue fibrosis which leads to poor tendon function is a worldwide clinical
problem; however, its mechanism remains unclear. Transcription factor RelA/p65, an …

Molecular pathways: the balance between cancer and the immune system challenges the therapeutic specificity of targeting nuclear factor-κB signaling for cancer …

KP Zeligs, MK Neuman, CM Annunziata - Clinical Cancer Research, 2016 - AACR
The NF-κB signaling pathway is a complex network linking extracellular stimuli to cell
survival and proliferation. Cytoplasmic signaling to activate NF-κB can occur as part of the …

Negative regulation of NF-κB p65 activity by serine 536 phosphorylation

JP Pradère, C Hernandez, C Koppe, RA Friedman… - Science …, 2016 - science.org
Nuclear factor κB (NF-κB) is a master regulator of inflammation and cell death. Whereas
most of the activity of NF-κB is regulated through the inhibitor of κB (IκB) kinase (IKK) …

Transplantation of bone marrow mesenchymal stromal cells attenuates liver fibrosis in mice by regulating macrophage subtypes

XY Luo, XJ Meng, DC Cao, W Wang, K Zhou… - Stem Cell Research & …, 2019 - Springer
Background Liver fibrosis is a key phase that will progress to further injuries such as liver
cirrhosis or carcinoma. This study aimed to investigate whether transplantation of bone …

Study on the mechanism of astragalus polysaccharide in treating pulmonary fibrosis based on “Drug-Target-Pathway” network

P Bing, W Zhou, S Tan - Frontiers in Pharmacology, 2022 - frontiersin.org
Pulmonary fibrosis is a chronic, progressive and irreversible heterogeneous disease of
pulmonary interstitial tissue. Its incidence is increasing year by year in the world, and it will …

MicroRNA-21-3p engineered umbilical cord stem cell-derived exosomes inhibit tendon adhesion

Z Yao, J Li, X Wang, S Peng, J Ning… - Journal of …, 2020 - Taylor & Francis
Purpose As a common complication of tendon injury, tendon adhesion is an unresolved
problem in clinical work. The aim of this study was to investigate whether human umbilical …