Recent advance in oxazole-based medicinal chemistry

HZ Zhang, ZL Zhao, CH Zhou - European journal of medicinal chemistry, 2018 - Elsevier
Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic
ring are readily able to bind with a variety of enzymes and receptors in biological systems …

Oxazole and isoxazole: From one-pot synthesis to medical applications

A Thakur, M Verma, R Bharti, R Sharma - Tetrahedron, 2022 - Elsevier
N, O-containing five-membered heterocycles especially oxazole and isoxazole, have widely
been found in many natural products and drugs with relevant medicinal and pharmaceutical …

Recent advancement in the discovery and development of COX-2 inhibitors: Insight into biological activities and SAR studies (2008–2019)

V Sharma, P Bhatia, O Alam, MJ Naim, F Nawaz… - Bioorganic …, 2019 - Elsevier
Cyclooxygenase-2 is a very important physiological enzyme playing key roles in various
biological functions especially in the mechanism of pain and inflammation, among other …

Synthetic transformations and biological screening of benzoxazole derivatives: A review

R Sattar, R Mukhtar, M Atif… - Journal of Heterocyclic …, 2020 - Wiley Online Library
The presence of benzoxazole moiety in most of the heterocyclic compounds is well reported.
The present literature review mainly highlights the novel synthetic transformation and …

Piperazine: a promising scaffold with analgesic and anti-inflammatory potential

A Jain, J Chaudhary, H Khaira, B Chopra… - Drug …, 2021 - thieme-connect.com
Piperazine, a nitrogen-containing heterocyclic has acquired an inimitable position in
medicinal chemistry because of its versatile structure, which has fascinated researchers to …

Design, synthesis, molecular docking, and ADME prediction evaluation of phenyloxazole derivatives as α-glucosidase inhibitors

M Fan, W Yang, Z Peng, G Wang - Journal of Molecular Structure, 2023 - Elsevier
A class of new phenyloxazole derivatives (6a-6p) was synthesized, and their inhibitory
activities towards α-glucosidase were researched. All synthesized compounds displayed …

Oxazolyl-pyrimidines as antibacterial and antitubercular agents: synthesis, biological evaluation, in-silico ADMET and molecular docking study

KD Katariya, DV Reddy - Journal of Molecular Structure, 2022 - Elsevier
In search of novel biologically potent compounds, some new oxazolyl pyrimidines (7a-g)
have been prepared in the current investigation. All new compounds were characterized …

[PDF][PDF] Systematic scientific study of 1, 3-oxazole derivatives as a useful lead for pharmaceuticals: A review

S Joshi, AS Bisht, D Juyal - The Pharma Innovation, 2017 - academia.edu
Oxazole contain an oxygen atom and a pyridine type nitrogen atom at the 1 and 3 positions
of the ring and like pyridine, oxazole are weekly basic substances. Oxazole be considered …

Quinoline‐1, 3‐Oxazole hybrids: syntheses, anticancer activity and molecular docking studies

SR Shah, KD Katariya, D Reddy - ChemistrySelect, 2020 - Wiley Online Library
In continuation of the synthesis of potent quinoline based anticancer agents, a series of
novel quinoline‐1, 3‐oxazole hybrids 15 a‐l were synthesized by the condensation reaction …

Contemporary advances of cyclic molecules proposed for inflammation

K Neha, S Wakode - European Journal of Medicinal Chemistry, 2021 - Elsevier
This review stretches insight about the advancement (2011–2021) of synthesized non-
heterocyclic, heterocyclic and natural occurring cyclic molecules for inflammation. While …