Post-translational modifications of cellular substrates with ubiquitin and ubiquitin-like
proteins (UBLs), including ubiquitin, SUMOs, and neural precursor cell–expressed …

Background The neddylation pathway is overactivated in human cancers. Inhibition of
neddylation pathway has emerged as an attractive anticancer strategy. The mechanisms …

As a protein that resembles ubiquitin, neural precursor cell expressed developmentally
downregulated 8 (NEDD8) takes part in neddylation, which modifies substrates in a manner …

Pevonedistat is a potent, selective, first-in-class NEDD8 activating enzyme inhibitor. It is now
under multiple clinical trials that investigate its anticancer effect against solid tumors and …

Objective: The hyperactivated neddylation pathway plays an important role in tumorigenesis
and is emerging as a promising anticancer target. We aimed to study whether NEDD8 …

This book presents an experimental and computational account of the applications of
biopolymers in the field of medicine. Biopolymers are macromolecules produced by living …

Intrahepatic cholangiocarcinoma (ICC) accounts for approximately 15% of primary liver
cancers, and the incidence rate has been increasing in recent years. Surgical resection is …

Plant derived product can be used as other alternatives to currently used drugs for
controlling chronic diseases like D iabetes mellitus. The potential of Coagulin L (a …

MLN4924 is an experimental cancer drug known as inhibitor of NEDD8-activating enzyme
(NAE). This anti-tumor candidate is a selective small-molecule inhibitor of NAE which is …

Background: Intrahepatic cholangiocarcinoma (ICC) accounts for about 15% of primary liver
cancer, and the incidence rate has been rising in recent years. Surgical resection is the best …