Cyclin-dependent kinases (CDKs) regulate the cell division cycle, apoptosis, transcription
and differentiation in addition to functions in the nervous system. Deregulation of CDKs in …

Protein kinases have a fundamental role in signal transduction pathways, and aberrant
kinase activity has been observed in many diseases. In recent years, kinase inhibition has …

A pharmacological approach to inhibition of cyclin-dependent kinases 4 and 6 (Cdk4/6)
using highly selective small molecule inhibitors has the potential to provide novel cancer …

Paullones constitute a new family of benzazepinones with promising antitumoral properties.
They were recently described as potent, ATP‐competitive, inhibitors of the cell cycle …

GSK-3β is a regulatory serine/threonine kinase with a plethora of cellular targets.
Consequently, selective small molecule inhibitors of GSK-3β may have a variety of …

Background Flavopiridol, a flavonoid currently in cancer clinical trials, inhibits cyclin-
dependent kinases (CDKs) by competitively blocking their ATP-binding pocket. However …

Two closely related classes of oxindole-based compounds, 1 H-indole-2, 3-dione 3-
phenylhydrazones and 3-(anilinomethylene)-1, 3-dihydro-2 H-indol-2-ones, were shown to …

Inhibition of the cell cycle kinase, cyclin-dependent kinase-4 (Cdk4), is expected to provide
an effective method for the treatment of proliferative diseases such as cancer. The pyrido [2 …

Protein serine-threonine kinase casein kinase II (CK2) is involved in a myriad of cellular
processes including cell growth and proliferation through its phosphorylation of hundreds of …

Kenpaullone derivatives with a modified parent ring system were synthesized in order to
develop kinase inhibitors with enhanced selectivity. Among the novel structures, 1 …