Transcriptomics for child and adolescent tuberculosis

M Kaforou, C Broderick, O Vito, M Levin… - Immunological …, 2022 - Wiley Online Library
Tuberculosis (TB) in humans is caused by Mycobacterium tuberculosis (Mtb). It is estimated
that 70 million children (< 15 years) are currently infected with Mtb, with 1.2 million each year …

Biomarkers for diagnosis of childhood tuberculosis: a systematic review

TO Togun, E MacLean, B Kampmann, M Pai - PloS one, 2018 - journals.plos.org
Introduction As studies of biomarkers of tuberculosis (TB) disease provide hope for a simple,
point-of-care test, we aimed to synthesize evidence on biomarkers for diagnosis of TB in …

Associations between systemic inflammation, mycobacterial loads in sputum and radiological improvement after treatment initiation in pulmonary TB patients from …

EDD Mesquita, L Gil-Santana, D Ramalho… - BMC infectious …, 2016 - Springer
Background Mycobacterium tuberculosis infection is known to cause inflammation and lung
tissue damage in high-risk populations. Nevertheless, direct associations between …

Novel RNA biomarkers improve discrimination of children with tuberculosis disease from those with non-TB pneumonia after in vitro stimulation

O Vito, S Psarras, A Syggelou, VJ Wright… - Frontiers in …, 2024 - frontiersin.org
The diagnosis of pediatric tuberculosis (TB) poses a challenge for clinical teams worldwide.
TB-mediated changes in the expression of host genes in the peripheral blood can serve as …

Novel transcriptional signatures for sputum-independent diagnostics of tuberculosis in children

JE Gjøen, S Jenum, D Sivakumaran, A Mukherjee… - Scientific reports, 2017 - nature.com
Pediatric tuberculosis (TB) is challenging to diagnose, confirmed by growth of
Mycobacterium tuberculosis at best in 40% of cases. The WHO has assigned high priority to …

Pediatric tuberculosis: the impact of “omics” on diagnostics development

S Jakhar, AA Bitzer, LR Stromberg… - International journal of …, 2020 - mdpi.com
Tuberculosis (TB) is a major public health concern for all ages. However, the disease
presents a larger challenge in pediatric populations, partially owing to the lack of reliable …

Brazil's first free-mating laboratory colony of Nyssorhynchus darlingi

MS Araujo, AO Andrade, NAC Santos… - Revista da Sociedade …, 2019 - SciELO Brasil
INTRODUCTION: The lack of highly-productive Nyssorhynchus darlingi laboratory colonies
limits some studies. We report the first well-established laboratory colony of Ny. darlingi in …

Host blood RNA transcript and protein signatures for sputum-independent diagnostics of tuberculosis in adults

D Sivakumaran, C Ritz, JE Gjøen, M Vaz… - Frontiers in …, 2021 - frontiersin.org
To achieve the ambitious targets for tuberculosis (TB) prevention, care, and control stated by
the End TB Strategy, new health care strategies, diagnostic tools are warranted. Host …

A protein signature associated with active tuberculosis identified by plasma profiling and network-based analysis

Z Mousavian, E Folkesson, G Fröberg, F Foroogh… - Iscience, 2022 - cell.com
Annually, approximately 10 million people are diagnosed with active tuberculosis (TB), and
1.4 million die of the disease. If left untreated, each person with active TB will infect 10–15 …

Combining host-derived biomarkers with patient characteristics improves signature performance in predicting tuberculosis treatment outcomes

D Sivakumaran, S Jenum, M Vaz, S Selvam… - Communications …, 2020 - nature.com
Tuberculosis (TB) is a global health concern. Treatment is prolonged, and patients on anti-
TB therapy (ATT) often experience treatment failure for various reasons. There is an urgent …