[HTML][HTML] Hypericum perforatum L. and the Underlying Molecular Mechanisms for Its Choleretic, Cholagogue, and Regenerative Properties
A Mohagheghzadeh, P Badr, A Mohagheghzadeh… - Pharmaceuticals, 2023 - mdpi.com
Any defects in bile formation, secretion, or flow may give rise to cholestasis, liver fibrosis,
cirrhosis, and hepatocellular carcinoma. As the pathogenesis of hepatic disorders is …
cirrhosis, and hepatocellular carcinoma. As the pathogenesis of hepatic disorders is …
[HTML][HTML] Contribution of Nischarin/IRAS in CNS development, injury and diseases
P Zheng, C Pan, C Zhou, B Liu, L Wang, S Duan… - Journal of Advanced …, 2023 - Elsevier
Abstract Background Murine Nischarin and its human homolog IRAS are scaffold proteins
highly expressed in the central nervous system (CNS). Nischarin was initially discovered as …
highly expressed in the central nervous system (CNS). Nischarin was initially discovered as …
[HTML][HTML] Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function
ZH Yang, X Cai, ZL Ding, W Li, CY Zhang, JH Huo… - BMC medicine, 2023 - Springer
Background Schizophrenia and bipolar disorder (BD) are believed to share clinical
symptoms, genetic risk, etiological factors, and pathogenic mechanisms. We previously …
symptoms, genetic risk, etiological factors, and pathogenic mechanisms. We previously …
[HTML][HTML] Analysis of the nischarin expression across human tumor types reveals its context-dependent role and a potential as a target for drug repurposing in oncology
M Ostojić, A Đurić, K Živić, J Grahovac - Plos one, 2024 - journals.plos.org
Nischarin was reported to be a tumor suppressor that plays a critical role in breast cancer
initiation and progression, and a positive prognostic marker in breast, ovarian and lung …
initiation and progression, and a positive prognostic marker in breast, ovarian and lung …
Nischarin expression may have differing roles in male and female melanoma patients
M Ostojić, M Jevrić, O Mitrović-Ajtić, K Živić… - Journal of Molecular …, 2023 - Springer
Due to the development of resistance to previously effective therapies, there is a constant
need for novel treatment modalities for metastatic melanoma. Nischarin (NISCH) is a …
need for novel treatment modalities for metastatic melanoma. Nischarin (NISCH) is a …
UBTF mediates activation of L3MBTL2 to suppress NISCH expression through histone H2AK119 monoubiquitination modification in breast cancer
K Chen, Y Dong, G He, X He, M Pan, X Huang… - Clinical & Experimental …, 2024 - Springer
Abstract Lethal (3) malignant brain tumor-like protein 2 (L3MBTL2) has been related to
transcriptional inhibition and chromatin compaction. Nevertheless, the biological functions …
transcriptional inhibition and chromatin compaction. Nevertheless, the biological functions …
Nischarin inhibits the epithelial-mesenchymal transition process and angiogenesis in breast cancer cells by inactivating FAK/ERK signaling pathway via EGF like …
R Zheng, Y He, L Yang, Y Chen, R Wang… - Molecular Biology Reports, 2024 - Springer
Background Our previous study has demonstrated that Nischarin (NISCH) exerts its
antitumor effects in breast cancer (BC) by suppressing cell migration and invasion. This …
antitumor effects in breast cancer (BC) by suppressing cell migration and invasion. This …
[HTML][HTML] Clinical significance of downregulated NISCH expression in skin cutaneous melanoma: Modulation of tumor cell invasion, migration, and EMT via PAK1 …
HK Hua, HM Zhu, ZG Zhang - Tissue and Cell, 2024 - Elsevier
Objective This study aimed to investigate the expression and functional role of NISCH in skin
cutaneous melanoma (SKCM), exploring its association with clinical characteristics and its …
cutaneous melanoma (SKCM), exploring its association with clinical characteristics and its …
Evolution of soft-shell clam transmissible cancer
SFM Hart - 2023 - search.proquest.com
Transmissible cancers are infectious parasitic clones that metastasize to new hosts, living
past the death of the founder animal in which the cancer initiated. Using genomic and …
past the death of the founder animal in which the cancer initiated. Using genomic and …
Pan-cancer analysis reveals that nischarin may not be the universal tumor suppressor
Background: Scaffolding protein nischarin (NISCH) was reported to be a tumor suppressor
that plays a critical role in breast cancer initiation and progression through regulation of the …
that plays a critical role in breast cancer initiation and progression through regulation of the …