Cells are equipped with numerous sensors that recognize nucleic acids, which probably
evolved for defence against viruses. Once triggered, these sensors stimulate the production …

Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …

In dry age-related macular degeneration (AMD), LCN2 (lipocalin 2) is upregulated. Whereas
LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here …

The activation of the cyclic GMP-AMP synthase-stimulator of interferon gene (STING)
pathway has been associated with the pathogenesis of many autoimmune and inflammatory …

The cGMP-AMP Synthase (cGAS)-Stimulator of Interferon Genes (STING) pathway plays a
critical role in sensing dsDNA localized to the cytosol, resulting in the activation of a robust …

During Inflammaging, a dysregulation of the immune cell functions is generated, and these
cells acquire a senescent phenotype with an increase in pro-inflammatory cytokines and …

DNA sensing is a pivotal component of the innate immune system that is responsible for
detecting mislocalized DNA and triggering downstream inflammatory pathways. Among the …

Combined treatment of immunotherapy and radiotherapy shows promising therapeutic
effects for the regression of a variety of cancers. However, even multi‐modality therapies …

Acute respiratory distress syndrome (ARDS) threatens the survival of critically ill patients, the
mechanisms of which are still unclear. Neutrophil extracellular traps (NETs) released by …

Pulmonary fibrosis is a progressive and ultimately fatal lung disease, exhibiting the
excessive production of extracellular matrix and aberrant activation of fibroblast. While …