Preclinical research is a vital step in the drug discovery pipeline and more generally in
helping to better understand human disease aetiology and its management. Systematic …

Boredom is an emotional state that occurs when an individual has nothing to do, is not
interested in the surrounding, and feels dreary and in a monotony. While this condition is …

Why can we still not translate preclinical research to clinical treatments for acute strokes?
Despite> 1000 successful preclinical studies, drugs, and concepts for acute stroke, only two …

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000035ileq01. jpg Objective To determine whether a change in editorial policy, including the …

Although the surge in research into the neuroscience of resilience is relatively new, it has
been able to elucidate the brain structures that underlie resilience and identify strategies for …

Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment
and dementia with limited therapeutic interventions. There is a critical need to provide …

In 2010, the NC3Rs published the Animal Research: Reporting of In Vivo Experiments
(ARRIVE) guidelines to improve the reporting of animal research. Despite considerable …

Acute ischaemic stroke can induce secondary brain injury by activating an inflammatory
response that contributes to clinical impairment. As a specific inhibitor of the …

Preclinical systematic reviews (SRs) and meta-analyses (MAs) are important research
activities to address the translational challenges of pain research. Systematic reviews …

There is a widely acknowledged need to improve the reliability and efficiency of scientific
research to increase the credibility of the published scientific literature and accelerate …