[HTML][HTML] Advances in antibody phage display technology
Phage display technology can be used for the discovery of antibodies for research,
diagnostic, and therapeutic purposes. In this review, we present and discuss key parameters …
diagnostic, and therapeutic purposes. In this review, we present and discuss key parameters …
[HTML][HTML] Advances in computational structure-based antibody design
Antibodies are currently the most important class of biotherapeutics and are used to treat
numerous diseases. Recent advances in computational methods are ushering in a new era …
numerous diseases. Recent advances in computational methods are ushering in a new era …
Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants
Neutralizing antibodies (nAbs) elicited against the receptor binding site (RBS) of the spike
protein of wild-type severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are …
protein of wild-type severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are …
IgM antibodies derived from memory B cells are potent cross-variant neutralizers of SARS-CoV-2
Humoral immunity to SARS-CoV-2 can be supplemented with polyclonal sera from
convalescent donors or an engineered monoclonal antibody (mAb) product. While …
convalescent donors or an engineered monoclonal antibody (mAb) product. While …
Monoclonal antibodies for COVID-19 therapy and SARS-CoV-2 detection
Abstract The coronavirus disease 2019 (COVID-19) pandemic is an exceptional public
health crisis that demands the timely creation of new therapeutics and viral detection. Owing …
health crisis that demands the timely creation of new therapeutics and viral detection. Owing …
Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2
X Rao, R Zhao, Z Tong, S Guo… - Proceedings of the …, 2023 - National Acad Sciences
Currently, monoclonal antibodies (MAbs) targeting the SARS-CoV-2 receptor binding
domain (RBD) of spike (S) protein are classified into seven classes based on their binding …
domain (RBD) of spike (S) protein are classified into seven classes based on their binding …
Protective neutralizing epitopes in SARS‐CoV‐2
H Liu, IA Wilson - Immunological reviews, 2022 - Wiley Online Library
The COVID‐19 pandemic has caused an unprecedented health crisis and economic burden
worldwide. Its etiological agent SARS‐CoV‐2, a new virus in the coronavirus family, has …
worldwide. Its etiological agent SARS‐CoV‐2, a new virus in the coronavirus family, has …
A pandemic-enabled comparison of discovery platforms demonstrates a naïve antibody library can match the best immune-sourced antibodies
As a result of the SARS-CoV-2 pandemic numerous scientific groups have generated
antibodies against a single target: the CoV-2 spike antigen. This has provided an …
antibodies against a single target: the CoV-2 spike antigen. This has provided an …
Epitope profiling using computational structural modelling demonstrated on coronavirus-binding antibodies
Identifying the epitope of an antibody is a key step in understanding its function and its
potential as a therapeutic. Sequence-based clonal clustering can identify antibodies with …
potential as a therapeutic. Sequence-based clonal clustering can identify antibodies with …
Targeting the spike receptor binding domain class V Cryptic Epitope by an antibody with Pan-Sarbecovirus activity
Novel therapeutic monoclonal antibodies (MAbs) must accommodate comprehensive
breadth of activity against diverse sarbecoviruses and high neutralization potency to …
breadth of activity against diverse sarbecoviruses and high neutralization potency to …