The IL-1 family of cytokines consists of IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, and IL-36γ.
These proteins form four signaling receptor complexes: the IL-1 receptor (IL-1R1 and IL …

Hyperlipidemia is confirmed to be associated with several health problems that include the
combination of diabetes mellitus, obesity, and hypertension, ie, metabolic syndrome …

Hydrogen–Deuterium exchange mass spectrometry's (HDX-MS) utility in identifying and
characterizing protein–small molecule interaction sites has been established. The regions …

IL-33 is a relatively new member of the IL-1 cytokine family, which plays a unique role in
autoimmune diseases, particularly some oral diseases dominated by immune factors. The IL …

Interleukin-33 (IL-33) belongs to the interleukin-1 (IL-1) family, and its structure is similar to
IL-18. When cells are damaged or undergo necrosis, mature form of IL-33 is secreted as a …

Cancer is a major cause of death worldwide and especially in high-and upper-middle-
income countries. Despite recent progress in cancer therapies, such as chimeric antigen …

Redesigning protein-protein interfaces is an important tool for developing therapeutic
strategies. Interfaces can be redesigned by in silico screening, which allows for efficient …

Abstract IL-1α and IL-1β are both involved in several aspects of tumor biology, including
tumor initiation, progression, metastasis, and not least in resistance to various therapies. IL …

Although computational structure prediction has had great successes in recent years, it
regularly fails to predict the interactions of large protein complexes with residue-level …

Background Deficiency in blood coagulation factor VIII (FVIII) results in life‐threating
bleeding (hemophilia A) treated by infusions of FVIII concentrates. To improve disease …