Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

The role of the prefrontal cortex (PFC) takes center stage among unanswered questions in
modern neuroscience. The PFC has a Janus-faced nature: it enables sophisticated cognitive …

The mammalian cerebral cortex has an unparalleled diversity of cell types, which are
generated during development through a series of temporally orchestrated events that are …

The neocortex contains a multitude of cell types that are segregated into layers and
functionally distinct areas. To investigate the diversity of cell types across the mouse …

In the mammalian cerebral cortex neurons are arranged in specific layers and form
connections both within the cortex and with other brain regions, thus forming a complex …

Radial glia, the neural stem cells of the neocortex, are located in two niches: the ventricular
zone and outer subventricular zone. Although outer subventricular zone radial glia may …

Genetic mosaicism is the result of the accumulation of somatic mutations in the human
genome starting from the first postzygotic cell generation and continuing throughout the …

Neural stem and progenitor cells (NSPCs) generate neurons throughout life in the
mammalian hippocampus. We used chronic in vivo imaging and followed genetically …

Focal cortical dysplasia (FCD) and hemimegalencephaly (HME) are epileptogenic
neurodevelopmental malformations caused by mutations in mTOR pathway genes. Deep …

New neurons arise from quiescent adult neural progenitors throughout life in specific
regions of the mammalian brain. Little is known about the embryonic origin and …